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Molecules 2018, 23(12), 3229; https://doi.org/10.3390/molecules23123229

Molecular and Functional Interaction of the Myokine Irisin with Physical Exercise and Alzheimer’s Disease

1,2,3,†
,
1,2,3,†
,
1,2,3
,
2,3,4
,
5
and
1,2,3,4,6,*
1
Department of Rehabilitation Science, Graduate School of Inje University, Gimhae 50834, Korea
2
Biohealth Products Research Center (BPRC), Inje University, Gimhae 50834, Korea
3
Ubiquitous Healthcare & Anti-Aging Research Center (u-HARC), Inje University, Gimhae 50834, Korea
4
Department of Physical Therapy, Graduate School of Inje University, Gimhae 50834, Korea
5
National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang 50834, Korea
6
Department of Physical Therapy, College of Healthcare Medical Science & Engineering, Gimhae 50834, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Jia Zhou
Received: 2 November 2018 / Revised: 3 December 2018 / Accepted: 5 December 2018 / Published: 7 December 2018
(This article belongs to the Special Issue Neuroprotective Agents)
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Abstract

Irisin, a skeletal muscle-secreted myokine, produced in response to physical exercise, has protective functions in both the central and the peripheral nervous systems, including the regulation of brain-derived neurotrophic factors. In particular, irisin is capable of protecting hippocampus. Since this area is the region of the brain that is most susceptible to Alzheimer’s disease (AD), such beneficial effect may inhibit or delay the emergence of neurodegenerative diseases, including AD. Also, the factors engaged in irisin formation appear to suppress Aβ aggregation, which is the pathological hallmark of AD. This review is based on the hypothesis that irisin produced by physical exercise helps to control AD progression. Herein, we describe the physiology of irisin and its potential role in delaying or preventing AD progression in human. View Full-Text
Keywords: physical exercise; irisin; neurodegeneration; Alzheimer’s disease physical exercise; irisin; neurodegeneration; Alzheimer’s disease
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Jin, Y.; Sumsuzzman, D.M.; Choi, J.; Kang, H.; Lee, S.-R.; Hong, Y. Molecular and Functional Interaction of the Myokine Irisin with Physical Exercise and Alzheimer’s Disease. Molecules 2018, 23, 3229.

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