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Molecules 2019, 24(3), 622;

Gastroprotection of Calein D against Ethanol-Induced Gastric Lesions in Mice: Role of Prostaglandins, Nitric Oxide and Sulfhydryls

Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Santo Tomás, Delegación Miguel Hidalgo, Ciudad de México 11340, Mexico
Facultad de Estudios Superiores Zaragoza, UNAM. Av. Guelatao No. 66, Colonia Ejército de Oriente Iztapalapa, Ciudad de México 09230, Mexico
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico
Unidad de Medicina Familiar No. 49, Instituto Mexicano del Seguro Social, Ciudad de México 06600, Mexico
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 10 January 2019 / Revised: 29 January 2019 / Accepted: 7 February 2019 / Published: 11 February 2019
(This article belongs to the Special Issue Natural Product Isolation, Identification and Biological Activity)
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Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from Calea urticifolia), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0.2 mL) after oral treatment with calein D at 3, 10 and 30 mg/kg, resulting in 13.15 ± 3.44%, 77.65 ± 7.38% and 95.76 ± 2.18% gastroprotection, respectively, to be compared with that of the control group. The effect found for 30 mg/kg of calein D was not reversed by pretreatment with NG-nitro-l-arginine methyl ester (l-NAME, 70 mg/kg, ip), indomethacin (10 mg/kg, sc) or N-ethylmaleimide (NEM, 10 mg/kg, sc). Hence, the mechanism of action of calein D does not involve NO, prostaglandins or sulfhydryl compounds. Calein D was more potent than carbenoxolone, the reference drug. The findings for the latter are in agreement with previous reports. View Full-Text
Keywords: calein D; gastroprotection; gastric ulcer; Calea urticifolia; sesquiterpene lactones calein D; gastroprotection; gastric ulcer; Calea urticifolia; sesquiterpene lactones

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sánchez-Mendoza, M.E.; López-Lorenzo, Y.; Cruz-Antonio, L.; Matus-Meza, A.-S.; Sánchez-Mendoza, Y.; Arrieta, J. Gastroprotection of Calein D against Ethanol-Induced Gastric Lesions in Mice: Role of Prostaglandins, Nitric Oxide and Sulfhydryls. Molecules 2019, 24, 622.

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