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Molecules 2019, 24(3), 611; https://doi.org/10.3390/molecules24030611

An Organic Chemist’s Guide to Electrospray Mass Spectrometric Structure Elucidation

1
Hevesy György PhD School of Chemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/A, 1117 Budapest, Hungary
2
Department of Analytical Chemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/A, 1117 Budapest, Hungary
*
Author to whom correspondence should be addressed.
Received: 16 January 2019 / Revised: 7 February 2019 / Accepted: 8 February 2019 / Published: 10 February 2019
(This article belongs to the Section Organic Chemistry)
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Abstract

Tandem mass spectrometry is an important tool for structure elucidation of natural and synthetic organic products. Fragmentation of odd electron ions (OE+) generated by electron ionization (EI) was extensively studied in the last few decades, however there are only a few systematic reviews available concerning the fragmentation of even-electron ions (EE+/EE) produced by the currently most common ionization techniques, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). This review summarizes the most important features of tandem mass spectra generated by collision-induced dissociation fragmentation and presents didactic examples for the unexperienced users. View Full-Text
Keywords: tandem mass spectrometry; MS/MS fragmentation; collision-induced dissociation; CID; ESI; structure elucidation tandem mass spectrometry; MS/MS fragmentation; collision-induced dissociation; CID; ESI; structure elucidation
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Steckel, A.; Schlosser, G. An Organic Chemist’s Guide to Electrospray Mass Spectrometric Structure Elucidation. Molecules 2019, 24, 611.

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