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Open AccessReview

Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

by Yongming Li 1,2, Huifei Zhong 1,2, Yanyan Huang 1,2,* and Rui Zhao 1,2
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
University of Chinese Academy of Sciences, Beijing 100049, China
Author to whom correspondence should be addressed.
Academic Editor: F. Christopher Pigge
Molecules 2019, 24(24), 4593;
Received: 15 November 2019 / Revised: 9 December 2019 / Accepted: 11 December 2019 / Published: 16 December 2019
(This article belongs to the Special Issue Aggregation-Induced Emission: Materials and Applications)
Metal ions play important roles in biological system. Approaches capable of selective and sensitive detection of metal ions in living biosystems provide in situ information and have attracted remarkable research attentions. Among these, fluorescence probes with aggregation-induced emission (AIE) behavior offer unique properties. A variety of AIE fluorogens (AIEgens) have been developed in the past decades for tracing metal ions. This review highlights recent advances (since 2015) in AIE-based sensors for detecting metal ions in biological systems. Major concerns will be devoted to the design principles, sensing performance, and bioimaging applications. View Full-Text
Keywords: metal ions; aggregation-induced emission; biosensing; bioimaging metal ions; aggregation-induced emission; biosensing; bioimaging
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MDPI and ACS Style

Li, Y.; Zhong, H.; Huang, Y.; Zhao, R. Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging. Molecules 2019, 24, 4593.

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