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Open AccessArticle

Plant-Mediated Enantioselective Transformation of Indan-1-one and Indan-1-ol. Part 2

1
Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland
2
Department of Genetics, Plant Breeding and Seed Production, Wroclaw University of Environmental and Life Sciences Pl. Grunwaldzki 24A, 53-363 Wroclaw, Poland
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(23), 4342; https://doi.org/10.3390/molecules24234342
Received: 31 October 2019 / Revised: 14 November 2019 / Accepted: 25 November 2019 / Published: 27 November 2019
(This article belongs to the Special Issue Chemoenzymatic Synthesis and Application)
The main purpose of this publication was to obtain the S-enantiomer of indan-1-ol with high enantiomeric excess and satisfactory yield. In our research, we used carrot callus cultures (Daucus carota L.), whereby the enzymatic system reduced indan-1-one and oxidized indan-1-ol. During the reaction of reduction, after five days, we received over 50% conversion, with the enantiomeric excess of the formed S-alcohol above 99%. In turn, during the oxidation of racemic indan-1-ol after 15 days, 36.7% of alcohol with an enantiomeric excess 57.4% S(+) remained in the reaction mixture. In addition, our research confirmed that the reactions of reduction and oxidation are competing reactions during the transformation of indan-1-ol and indan-1-one in carrot callus cultures. View Full-Text
Keywords: indan-1-one; indan-1-ol; biotransformation; reduction; oxidation; carrot; callus culture indan-1-one; indan-1-ol; biotransformation; reduction; oxidation; carrot; callus culture
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MDPI and ACS Style

Mączka, W.; Wińska, K.; Grabarczyk, M.; Galek, R. Plant-Mediated Enantioselective Transformation of Indan-1-one and Indan-1-ol. Part 2. Molecules 2019, 24, 4342. https://doi.org/10.3390/molecules24234342

AMA Style

Mączka W, Wińska K, Grabarczyk M, Galek R. Plant-Mediated Enantioselective Transformation of Indan-1-one and Indan-1-ol. Part 2. Molecules. 2019; 24(23):4342. https://doi.org/10.3390/molecules24234342

Chicago/Turabian Style

Mączka, Wanda; Wińska, Katarzyna; Grabarczyk, Małgorzata; Galek, Renata. 2019. "Plant-Mediated Enantioselective Transformation of Indan-1-one and Indan-1-ol. Part 2" Molecules 24, no. 23: 4342. https://doi.org/10.3390/molecules24234342

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