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Open AccessReview

Dihydrochalcones: Methods of Acquisition and Pharmacological Properties—A First Systematic Review

1
Institute of Medical Sciences, University of Rzeszów, 35-959 Rzeszów, Poland
2
Department of Biotechnology, Institute of Biology and Biotechnology, University of Rzeszów, 35-959 Rzeszów, Poland
3
Faculty of Chemistry, Rzeszow University of Technology, 35-959 Rzeszów, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Paola Vitale
Molecules 2019, 24(24), 4468; https://doi.org/10.3390/molecules24244468
Received: 9 October 2019 / Revised: 2 December 2019 / Accepted: 3 December 2019 / Published: 5 December 2019
(This article belongs to the Special Issue Chemoenzymatic Synthesis and Application)
Dihydrochalcones are a class of secondary metabolites, for which demand in biological and pharmacological applications is still growing. They posses several health-endorsing properties and, therefore, are promising candidates for further research and development. However, low content of dihydrochalcones in plants along with their low solubility and bioavailability restrict the development of these compounds as clinical therapeutics. Therefore, chemomicrobial and enzymatic modifications are required to expand their application. This review aims at analyzing and summarizing the methods of obtaining dihydrochalcones and of presenting their pharmacological actions that have been described in the literature to support potential future development of this group of compounds as novel therapeutic drugs. We have also performed an evaluation of the available literature on beneficial effects of dihydrochalcones with potent antioxidant activity and multifactorial pharmacological effects, including antidiabetic, antitumor, lipometabolism regulating, antioxidant, anti-inflammatory, antibacterial, antiviral, and immunomodulatory ones. In addition, we provide useful information on their properties, sources, and usefulness in medicinal chemistry. View Full-Text
Keywords: antioxidants; dihydrochalcones; microbial transformations; phloretin; sweeteners antioxidants; dihydrochalcones; microbial transformations; phloretin; sweeteners
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MDPI and ACS Style

Stompor, M.; Broda, D.; Bajek-Bil, A. Dihydrochalcones: Methods of Acquisition and Pharmacological Properties—A First Systematic Review. Molecules 2019, 24, 4468.

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