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Article

Effects of Blackcurrant Anthocyanin on Endothelial Function and Peripheral Temperature in Young Smokers

1
Department of Nursing Sciences, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
2
Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki-shi, Aomori-ken 036-8564, Japan
3
Department of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki, Aomori 036-8561, Japan
4
College of Nursing, Taipei Medical University, 4 No. 250 Wuxing Street, Taipei 11031, Taiwan
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(23), 4295; https://doi.org/10.3390/molecules24234295
Received: 1 October 2019 / Revised: 15 November 2019 / Accepted: 18 November 2019 / Published: 25 November 2019
(This article belongs to the Special Issue Anthocyanins: Recent Progress in Health Benefits Studies)
Background: Blackcurrant anthocyanin (BCA) is expected to repair endothelial dysfunction, but it remains unclear whether beneficial effects are present in young healthy persons. This study examines whether supplements containing blackcurrant anthocyanin improve endothelial function and peripheral temperature in young smokers. Methods: Young, healthy male nonsmokers (N group: n = 11; mean age 22 ± 2 years) and smokers (S group: n = 13; mean age 21 ± 1 years) were enrolled. A randomized and double-blind trial was designed to compare the effects of no supplement, a supplement containing 50 mg of blackcurrant anthocyanin (supplement A), and a supplement containing 50 mg of blackcurrant anthocyanin plus vitamin E (supplement B) on flow-mediated dilatation (FMD) and skin temperature. Results: Under no supplement, FMD was unchanged during the 2 h period after smoking in the N group, whereas it was decreased during the 2 h period after smoking in the S group. Under the A supplement, FMD was decreased 1 h after smoking and returned to the baseline level 2 h after smoking in the S group. The skin temperature in the area of the foot dorsum was decreased in the S group after smoking compared with that in the N group, who did not smoke, whereas under A and B supplements, it was higher in the S group compared with that in the N group. Conclusions: BCA could attenuate the smoking-induced acute endothelial dysfunction and improve peripheral temperature in young smokers. View Full-Text
Keywords: blackcurrant; anthocyanin; smoking; peripheral temperature; endothelial function blackcurrant; anthocyanin; smoking; peripheral temperature; endothelial function
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MDPI and ACS Style

Tomisawa, T.; Nanashima, N.; Kitajima, M.; Mikami, K.; Takamagi, S.; Maeda, H.; Horie, K.; Lai, F.-c.; Osanai, T. Effects of Blackcurrant Anthocyanin on Endothelial Function and Peripheral Temperature in Young Smokers. Molecules 2019, 24, 4295. https://doi.org/10.3390/molecules24234295

AMA Style

Tomisawa T, Nanashima N, Kitajima M, Mikami K, Takamagi S, Maeda H, Horie K, Lai F-c, Osanai T. Effects of Blackcurrant Anthocyanin on Endothelial Function and Peripheral Temperature in Young Smokers. Molecules. 2019; 24(23):4295. https://doi.org/10.3390/molecules24234295

Chicago/Turabian Style

Tomisawa, Toshiko, Naoki Nanashima, Maiko Kitajima, Kasumi Mikami, Shizuka Takamagi, Hayato Maeda, Kayo Horie, Fu-chih Lai, and Tomohiro Osanai. 2019. "Effects of Blackcurrant Anthocyanin on Endothelial Function and Peripheral Temperature in Young Smokers" Molecules 24, no. 23: 4295. https://doi.org/10.3390/molecules24234295

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