Next Article in Journal
The Synthesis, Characterization, Cytotoxic Activity Assessment and Structure–Activity Relationship of 4-Aryl-6-(2,5-dichlorothiophen-3-yl)-2-methoxypyridine-3-carbonitriles
Previous Article in Journal
Synthesis and Fluorescent Properties of Novel Isoquinoline Derivatives
Previous Article in Special Issue
Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation
Open AccessArticle

α-Glucosidase and Pancreatic Lipase Inhibitory Activities of Diterpenes from Indian Mango Ginger (Curcuma amada Roxb.) and Its Derivatives

1
Natural products, Inabata Koryo Co., Ltd., Osaka 320027, Japan
2
Department of Applied Biological Chemistry, School of Agriculture, Kindai University, Nara 6318505, Japan
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(22), 4071; https://doi.org/10.3390/molecules24224071
Received: 12 October 2019 / Revised: 30 October 2019 / Accepted: 4 November 2019 / Published: 10 November 2019
(This article belongs to the Special Issue Discovery of Active Ingredients from Natural Products)
Enzymatic inhibitions of crude extracts and their constituents from Zingiberaceae against both rat intestinal α-glucosidase and porcine pancreatic lipase were investigated. Structure–activity relationships using their derivatives were also investigated. The rhizomes extract of mango ginger, Curcuma amada showed remarkable inhibitory activity in the screening test. Two natural labdane diterpenes 1 and 2 and a drimane sesquiterpene 3 were major constituents isolated from this hexane extract. Among them, (E)-labda-8(17),12-diene-15,16-dial (1) was the most prominent compound and showed inhibitory activity against both α-glucosidase and lipase. Derivatives 410 from compound 1 were prepared and evaluated using inhibitory assays with these enzymes. The reduced derivative 4 maintained α-glucosidase inhibitory activity, but had decreased pancreatic lipase inhibitory activity compared with parent compound 1. Other tested derivatives of compound 1, including acetates 57 and oxidative derivatives 8–10, had very weak α-glucosidase inhibitory activity. Most of these compounds showed moderate pancreatic lipase inhibitory activity. However, only sesquiterpene albicanal (3) showed drastically decreased pancreatic lipase activity compared with 1. These findings suggested that molecular size was essential for enzymatic inhibitory activities of these compounds. These results demonstrated that mango ginger may be useful for the prevention of obesity and being overweight. View Full-Text
Keywords: Curcuma amada Roxb.; diterpene; α-glucosidase inhibitor; pancreatic lipase inhibitor; anti-obesity Curcuma amada Roxb.; diterpene; α-glucosidase inhibitor; pancreatic lipase inhibitor; anti-obesity
Show Figures

Figure 1

MDPI and ACS Style

Yoshioka, Y.; Yoshimura, N.; Matsumura, S.; Wada, H.; Hoshino, M.; Makino, S.; Morimoto, M. α-Glucosidase and Pancreatic Lipase Inhibitory Activities of Diterpenes from Indian Mango Ginger (Curcuma amada Roxb.) and Its Derivatives. Molecules 2019, 24, 4071.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop