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Open AccessArticle

Synthesis and Fluorescent Properties of Novel Isoquinoline Derivatives

1
Department of Chemical Technology of Drugs, Faculty of Pharmacy, Medical University of Gdańsk, 80-416 Gdańsk, Poland
2
Faculty of Chemistry, Adam Mickiewicz University, 61-614 Poznań, Poland
*
Author to whom correspondence should be addressed.
Deceased 18 October 2018.
Molecules 2019, 24(22), 4070; https://doi.org/10.3390/molecules24224070
Received: 26 September 2019 / Revised: 18 October 2019 / Accepted: 8 November 2019 / Published: 10 November 2019
Isoquinoline derivatives have attracted great interest for their wide biological and fluorescent properties. In the current study, we focused on the synthesis of a series of novel isoquinoline derivatives substituted at position 3 of the heteroaromatic ring. Compounds were obtained in a Goldberg–Ullmann-type coupling reaction with appropriate amides in the presence of copper(I) iodide, N,N-dimethylethylenediamine (DMEDA), and potassium carbonate. The structures of novel isoquinolines were confirmed by IR, NMR, and elemental analysis, as well as X-ray crystallography. In the course of our research work, the visible fluorescence of this class of compounds was observed. The above findings prompted us to investigate the optical properties of the selected compounds. View Full-Text
Keywords: isoquinoline derivatives; copper-catalyzed coupling; fluorescence; X-ray crystallography isoquinoline derivatives; copper-catalyzed coupling; fluorescence; X-ray crystallography
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MDPI and ACS Style

Balewski, Ł.; Sączewski, F.; Gdaniec, M.; Kornicka, A.; Cicha, K.; Jalińska, A. Synthesis and Fluorescent Properties of Novel Isoquinoline Derivatives. Molecules 2019, 24, 4070.

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