Next Article in Journal
Penfluridol as a Candidate of Drug Repurposing for Anticancer Agent
Previous Article in Journal
Synthesis of Samarium-Based Metal Organic Compound Nanoparticles with Polychromatic-Photoluminescence for Bio-Tissue Fluorescence Imaging
Previous Article in Special Issue
Hydro/Deutero Deamination of Arylazo Sulfones under Metal- and (Photo)Catalyst-Free Conditions
Open AccessArticle

Development of a Telescoped Flow Process for the Safe and Effective Generation of Propargylic Amines

School of Chemistry, University College Dublin, Science Centre South, Belfield, Dublin 4, Ireland
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(20), 3658; https://doi.org/10.3390/molecules24203658
Received: 22 September 2019 / Revised: 7 October 2019 / Accepted: 8 October 2019 / Published: 10 October 2019
Propargylic amines are important multifunctional building blocks that are frequently exploited in the synthesis of privileged heterocyclic entities. Herein we report on a novel flow process that achieves the safe and effective on-demand synthesis of propargylic amines in a telescoped manner. This process minimizes exposure to hazardous azide intermediates and renders a streamlined route into these building blocks. The value of this approach is demonstrated by the rapid generation of a small selection of drug-like thiazolines that result from a high-yielding reaction cascade between propargylic amines with different aryl isothiocyanates. View Full-Text
Keywords: azides; flow chemistry; continuous process; propargylic amines; building block synthesis. azides; flow chemistry; continuous process; propargylic amines; building block synthesis.
Show Figures

Graphical abstract

MDPI and ACS Style

Donnelly, K.; Zhang, H.; Baumann, M. Development of a Telescoped Flow Process for the Safe and Effective Generation of Propargylic Amines. Molecules 2019, 24, 3658.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop