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Molecules 2019, 24(2), 273; https://doi.org/10.3390/molecules24020273

Castanopsis lamontii Water Extract Shows Potential in Suppressing Pathogens, Lipopolysaccharide-Induced Inflammation and Oxidative Stress-Induced Cell Injury

1
Tea Research Institute Chinese Academy of Agricultural Sciences, Ministry of Agriculture, Hangzhou 310008, China
2
College of Agricultural and Food Sciences, Zhejiang A & F University, Linan 311300, China
3
Department of Tea Science, Zhejiang University, Hangzhou 310058, China
4
Guelph Food Research and Development Center, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada
*
Authors to whom correspondence should be addressed.
Received: 22 November 2018 / Revised: 6 January 2019 / Accepted: 9 January 2019 / Published: 12 January 2019
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Abstract

Castanopsis lamontii is traditionally used to prevent inflammatory diseases such as periodontitis and pharyngitis by residents in southwest China. However, little scientific evidence has been found to support this. In this research, the antibacterial activities of Castanopsis lamontii water extract (CLE) were assessed using the micro-dilution method. The anti-inflammatory and antioxidant activities of CLE were investigated in RAW264.7 cells. Key bioactive compounds in CLE were also explored. Results showed that CLE was capable of inhibiting the periodontitis pathogen Porphyromonas gingivalis and the pharyngitis pathogen β-hemolytic Streptococcus. It suppressed lipopolysaccharide-induced inflammation in RAW 264.7 cells via inactivating the TLR4/NF-κB pathway. Besides, it reduced oxidative stress-induced cell injury via scavenging reactive oxygen species. Chemical composition analysis revealed that CLE was rich in epicatechin and procyanidin B2. Further studies confirmed that epicatechin predominantly contributed to the antibacterial activities of CLE, while procyanidin B2 was mainly responsible for the anti-inflammatory activities of CLE. Both compounds contributed to the antioxidant activities of CLE. Acute oral toxicity tests proved that CLE was practically non-toxic. These results provide experimental evidences of the health-beneficial effects of CLE and may help promote the application of CLE in the food and health industries. View Full-Text
Keywords: Castanopsis lamontii; epicatechin; procyanidin B2; anti-bacteria; anti-inflammation; antioxidant Castanopsis lamontii; epicatechin; procyanidin B2; anti-bacteria; anti-inflammation; antioxidant
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Gao, Y.; Zhang, X.; Yin, J.; Du, Q.; Tu, Y.; Shi, J.; Xu, Y. Castanopsis lamontii Water Extract Shows Potential in Suppressing Pathogens, Lipopolysaccharide-Induced Inflammation and Oxidative Stress-Induced Cell Injury. Molecules 2019, 24, 273.

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