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Open AccessArticle

The Influence of Essential Oil Compounds on Antibacterial Activity of Mupirocin-Susceptible and Induced Low-Level Mupirocin-Resistant MRSA Strains

1
Department of Diagnostic Immunology; Chair of Microbiology, Immunology and Laboratory Medicine; Pomeranian Medical University in Szczecin; 72 Powstancow Wielkopolskich Avenue, 70-111 Szczecin, Poland
2
Department of Laboratory Medicine; Chair of Microbiology, Immunology and Laboratory Medicine; Pomeranian Medical University in Szczecin; 72 Powstancow Wielkopolskich Avenue, 70-111 Szczecin, Poland
3
Institute of General Food Chemistry, Faculty of Biotechnology and Food Sciences; Lodz University of Technology; Stefanowskiego 4/10, 90-924 Lodz, Poland
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Department of Allergology and Respiratory Rehabilitation; Medical University of Lodz; Zeligowskiego 7/9, 90-752 Lodz, Poland
5
Center of Bioimmobilisation and Innovative Packaging Materials; Faculty of Food Sciences and Fisheries; West Pomeranian University of Technology Szczecin; Janickiego 35, 71-270 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(17), 3105; https://doi.org/10.3390/molecules24173105
Received: 25 July 2019 / Revised: 14 August 2019 / Accepted: 24 August 2019 / Published: 27 August 2019
(This article belongs to the Special Issue Essential Oils as Antimicrobial and Anti-infectious Agents II)
Because of the bacterial drug resistance development, it is reasonable to investigate chemical compounds capable of preventing the spread of resistance to mupirocin (MUP), commonly used in staphylococcal eradication. The objective of the study was to verify the influence of essential oil compounds (EOCs) on the antibacterial activity of MUP against mupirocin-susceptible (MupS) and induced low-level mupirocin-resistant (MupRL) methicillin-resistant Staphylococcus aureus (MRSA) strains. The following parameters were examined: MRSAMupS and MRSAMupRL susceptibility to EOCs (1,8-cineole, eugenol, carvacrol, linalool, (-)-menthone, linalyl acetate, and trans-anethole), the bacterial cell size distribution, and chemical composition by the use of Fourier Transform Infrared Spectroscopy (FTIR) and Raman spectroscopies. The MRSAMupS and MRSAMupRL strains were susceptible to all tested EOCs. 1,8-cineole and (-)-menthone showed synergistic activity against MRSAMupS in combination with mupirocin, whereas 1,8-cineole exhibited synergistic activity against MRSAMupRL as well. In-depth analysis showed that both MRSAMupS and MRSAMupRL displayed similar distributions of the bacterial cell size. The FTIR and Raman spectra of the MRSAMupS and MRSAMupRL strains showed differences in some regions. New bands in the MRSAMupRL Raman spectrum were observed. It was concluded that the use of 1,8-cineole in combination with mupirocin can increase the mupirocin activity against the MRSAMupS and MRSAMupRL strains. View Full-Text
Keywords: MRSA; mupirocin-susceptible; low-level mupirocin-resistant; essential oil compounds; synergistic activity; FTIR; Raman spectroscopy MRSA; mupirocin-susceptible; low-level mupirocin-resistant; essential oil compounds; synergistic activity; FTIR; Raman spectroscopy
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Kwiatkowski, P.; Pruss, A.; Wojciuk, B.; Dołęgowska, B.; Wajs-Bonikowska, A.; Sienkiewicz, M.; Mężyńska, M.; Łopusiewicz, Ł. The Influence of Essential Oil Compounds on Antibacterial Activity of Mupirocin-Susceptible and Induced Low-Level Mupirocin-Resistant MRSA Strains. Molecules 2019, 24, 3105.

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