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Open AccessArticle

Evaluation of the Antifungal Activity of Mentha x piperita (Lamiaceae) of Pancalieri (Turin, Italy) Essential Oil and Its Synergistic Interaction with Azoles

1
Department Public Health and Pediatrics, Microbiology Division, University of Turin, 10126 Turin, Italy
2
Area Servizi Alla Ricerca Polo Agraria e Medicina Veterinaria, University of Turin, 10095 Turin, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Daniela Rigano
Molecules 2019, 24(17), 3148; https://doi.org/10.3390/molecules24173148
Received: 6 August 2019 / Revised: 22 August 2019 / Accepted: 26 August 2019 / Published: 29 August 2019
(This article belongs to the Special Issue Essential Oils as Antimicrobial and Anti-infectious Agents II)
The promising antimicrobial activity of essential oils (EOs) has led researchers to use them in combination with antimicrobial drugs in order to reduce drug toxicity, side effects, and resistance to single agents. Mentha x piperita, known worldwide as “Mentha of Pancalieri”, is produced locally at Pancalieri (Turin, Italy). The EO from this Mentha species is considered as one of the best mint EOs in the world. In our research, we assessed the antifungal activity of “Mentha of Pancalieri” EO, either alone or in combination with azole drugs (fluconazole, itraconazole, ketoconazole) against a wide panel of yeast and dermatophyte clinical isolates. The EO was analyzed by GC-MS, and its antifungal properties were evaluated by minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) parameters, in accordance with the CLSI guidelines, with some modifications. The interaction of EO with azoles was evaluated through the chequerboard and isobologram methods. The results suggest that this EO exerts a fungicidal activity against yeasts and a fungistatic activity against dermatophytes. Interaction studies with azoles indicated mainly synergistic profiles between itraconazole and EO vs. Candida spp., Cryptococcus neoformans, and Trichophyton mentagrophytes. Thus, the “Mentha of Pancalieri” EO may act as a potential antifungal agent and could serve as a natural adjuvant for fungal infection treatment. View Full-Text
Keywords: essential oils; Mentha x piperita; “Mentha of Pancalieri”; azoles; antifungal activity; yeasts and dermatophytes; synergism essential oils; Mentha x piperita; “Mentha of Pancalieri”; azoles; antifungal activity; yeasts and dermatophytes; synergism
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MDPI and ACS Style

Tullio, V.; Roana, J.; Scalas, D.; Mandras, N. Evaluation of the Antifungal Activity of Mentha x piperita (Lamiaceae) of Pancalieri (Turin, Italy) Essential Oil and Its Synergistic Interaction with Azoles. Molecules 2019, 24, 3148.

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