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Polyphenol Effects on Splenic Cytokine Response in Post-Weaning Contactin 1-Overexpressing Transgenic Mice

1
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, School of Medicine, University of Bari, 70124 Bari, Italy
2
MEBIC Consortium, San Raffaele Open University of Rome and IRCCS San Raffaele Pisana of Rome, 00166 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Margarida Castell Escuer
Molecules 2019, 24(12), 2205; https://doi.org/10.3390/molecules24122205
Received: 17 May 2019 / Revised: 3 June 2019 / Accepted: 7 June 2019 / Published: 12 June 2019
(This article belongs to the Special Issue Natural Polyphenols and Health)
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Abstract

Background: In mice, postnatal immune development has previously been investigated, and evidence of a delayed maturation of the adaptive immune response has been detected. Methods: In this study, the effects of red grape polyphenol oral administration on the murine immune response were explored using pregnant mice (TAG/F3 transgenic and wild type (wt) mice) as the animal model. The study was performed during pregnancy as well as during lactation until postnatal day 8. Suckling pups from polyphenol-administered dams as well as day 30 post-weaning pups (dietary-administered with polyphenols) were used. Polyphenol effects were evaluated, measuring splenic cytokine secretion. Results: Phorbol myristate acetate-activated splenocytes underwent the highest cytokine production at day 30 in both wt and TAG/F3 mice. In the latter, release of interferon (IFN)-γ and tumor necrosis factor (TNF)-α was found to be higher than in the wt counterpart. In this context, polyphenols exerted modulating activities on day 30 TAG/F3 mice, inducing release of interleukin (IL)-10 in hetero mice while abrogating release of IL-2, IFN-γ, TNF-α, IL-6, and IL-4 in homo and hetero mice. Conclusion: Polyphenols are able to prevent the development of an inflammatory/allergic profile in postnatal TAG/F3 mice. View Full-Text
Keywords: cellular and molecular rehabilitation; contactins; cytokine; neonatal immunity; polyphenols; splenocytes cellular and molecular rehabilitation; contactins; cytokine; neonatal immunity; polyphenols; splenocytes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Magrone, T.; Spagnoletta, A.; Bizzoca, A.; Russo, M.A.; Jirillo, E.; Gennarini, G. Polyphenol Effects on Splenic Cytokine Response in Post-Weaning Contactin 1-Overexpressing Transgenic Mice. Molecules 2019, 24, 2205.

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