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Comparison of Phytochemical Differences of the Pulp of Different Peach [Prunus persica (L.) Batsch] Cultivars with Alpha-Glucosidase Inhibitory Activity Variations in China Using UPLC-Q-TOF/MS

1
Forestry and Fruit Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai, 201403, China
2
Shanghai Key Laboratory of Protected Horticultural Technology, Shanghai, 201403, China
3
Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai, 200240, China
*
Author to whom correspondence should be addressed.
Academic Editor: Claire Turner
Molecules 2019, 24(10), 1968; https://doi.org/10.3390/molecules24101968
Received: 23 April 2019 / Revised: 19 May 2019 / Accepted: 20 May 2019 / Published: 22 May 2019
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Abstract

In order to fully understand the variation of the fruit alpha-glucosidase inhibitory activity-related phytochemical basis in the Chinese peach [Prunus persica (L.) Batsch], mature fruit from 33 cultivars was used for the investigation of fruit phenolic phytochemical attributes, including total phenolics, flavonoids, anthocyanins, and procyanidins, as well as the alpha-glucosidase inhibitory activity in vitro. Alpha-glucosidase inhibitory activity varied significantly among tested peach cultivars and was strongly correlated with total phenolics, total procyanidins, and total flavonoids. Untargeted UPLC-Q-TOF/MS-based metabolomics were used to comprehensively discriminate between peaches with different inhibitory activity on alpha-glucosidase. Principal component analysis (PCA) and orthogonal partial least squares discrimination analysis (OPLS-DA) were used for this process. Twenty-three differential compounds were identified between peach cultivars with high and low alpha-glucosidase inhibitory activity, and nine, including procyanidin C1, procyanidin trimer isomer 1, procyanidin trimer isomer 2, procyanidin B1, procyanidin dimer, epicatechin-epicatechin-epicatechin, phloridzin, kaempferol 3-(2’’,6’’-di-(E)-p-coumarylglucoside), and luteolin 3’-methyl ether 7-malonylglucoside, were identified as marker compounds responsible for the discrimination. Overall, variations in metabolites in peach pulp reflect the diversity in peach germplasm, and these nine compounds are good candidate markers for future genetic breeding of peach fruit with high alpha-glucosidase inhibitory activity. View Full-Text
Keywords: Prunus persica pulp; phytochemicals; alpha-glucosidase inhibitory activity; UPLC-Q-TOF/MS; metabolomes; chemometrics; marker compounds; fruit quality Prunus persica pulp; phytochemicals; alpha-glucosidase inhibitory activity; UPLC-Q-TOF/MS; metabolomes; chemometrics; marker compounds; fruit quality
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Zhang, X.; Su, M.; Du, J.; Zhou, H.; Li, X.; Li, X.; Ye, Z. Comparison of Phytochemical Differences of the Pulp of Different Peach [Prunus persica (L.) Batsch] Cultivars with Alpha-Glucosidase Inhibitory Activity Variations in China Using UPLC-Q-TOF/MS. Molecules 2019, 24, 1968.

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