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An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance

1
Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia
2
Department of Information Technology, College of Computers and Information Technology, Taif University, Taif 5700, Saudi Arabia
3
Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia
4
Department of Medicinal chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 1441, Egypt
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(10), 1969; https://doi.org/10.3390/molecules24101969
Received: 7 April 2019 / Revised: 15 May 2019 / Accepted: 16 May 2019 / Published: 22 May 2019
(This article belongs to the Special Issue Chemical Biology of Antimicrobial Resistance)
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Abstract

Two series of novel 5-arylazo-3-cyano-2-(2″,3″,4″,6″-tetra-O-acetyl-β-d-galacto pyranosyloxy) pyridines and 3-cyano-2-(2″,3″,4″,6″-tetra-O-acetyl-β-d-galactopyranosyloxy) pyridines were synthesized in high yields utilizing a microwave-assisted synthesis tool guided by the principles of green chemistry. The chemical structures of the new substances were confirmed on the basis of their elemental analysis and spectroscopic data (FT-IR, 1D, 2D-NMR). Activity against different bacterial strains was studied. The anticancer potential of the new compounds is also discussed. Molecular docking was used as a tool in this research work to get better insight into the possible interactions, affinities, and expected modes of binding of the most promising derivatives of the potential chemotherapeutic target (DHFR). View Full-Text
Keywords: green chemistry; microwave synthesis; pyridine galactosides; anticancer activity; antimicrobial; molecular docking green chemistry; microwave synthesis; pyridine galactosides; anticancer activity; antimicrobial; molecular docking
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Alrobaian, M.; Azwari, S.A.; Belal, A.; Eldeab, H.A. An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance. Molecules 2019, 24, 1969.

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