New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity
Institute of Chemistry, Jan Kochanowski University, Świętokrzyska 15 G, 25-406 Kielce, Poland
Institute of Biology, Jan Kochanowski University, Świętokrzyska 15 G, 25-406 Kielce, Poland
Department of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wrocław, Poland
Department of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089 Warszawa, Poland
Department of Immunology and Infectious Biology, University of Lodz, Banacha 12/16, 90-237 Łódź, Poland
Author to whom correspondence should be addressed.
Received: 24 April 2019 / Revised: 7 May 2019 / Accepted: 9 May 2019 / Published: 15 May 2019
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This paper presents the synthesis of
-lactones from readily available organic substrates such as trans
-crotonaldehyde and aryl bromides. Crystal structure analysis was carried out for lactones that were obtained in crystalline form. All halo-
-lactones were highly cytotoxic against gastric cancer AGS cells with
values in the range of 0.0006–0.0044 mM. Some lactones showed high bactericidal activity against E. coli
ATCC 8739 and S. aureus
ATCC 65389, which reduced the number of CFU/mL by 70–83% and 87% respectively.
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Kamizela, A.; Gawdzik, B.; Urbaniak, M.; Lechowicz, Ł.; Białońska, A.; Kutniewska, S.E.; Gonciarz, W.; Chmiela, M. New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity. Molecules 2019, 24, 1875.
Kamizela A, Gawdzik B, Urbaniak M, Lechowicz Ł, Białońska A, Kutniewska SE, Gonciarz W, Chmiela M. New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity. Molecules. 2019; 24(10):1875.
Kamizela, Angelika; Gawdzik, Barbara; Urbaniak, Mariusz; Lechowicz, Łukasz; Białońska, Agata; Kutniewska, Sylwia E.; Gonciarz, Weronika; Chmiela, Magdalena. 2019. "New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity." Molecules 24, no. 10: 1875.
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