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Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted Delivery

1
Department of Nutrition, College of Rehabilitation, Kasprzaka 49, 01-234 Warsaw, Poland
2
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(10), 1873; https://doi.org/10.3390/molecules24101873
Received: 1 April 2019 / Revised: 8 May 2019 / Accepted: 14 May 2019 / Published: 15 May 2019
(This article belongs to the Special Issue Bioactive Molecules and Their Mechanisms of Action)
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Abstract

Recently, the fast development of hybrid nanogels dedicated to various applications has been seen. In this context, nanogels incorporating biomolecules into their nanonetworks are promising innovative carriers that gain great potential in biomedical applications. Hybrid nanogels containing various types of biomolecules are exclusively designed for: improved and controlled release of drugs, targeted delivery, improvement of biocompatibility, and overcoming of immunological response and cell self-defense. This review provides recent advances in this rapidly developing field and concentrates on: (1) the key physical consequences of using hybrid nanogels and introduction of biomolecules; (2) the construction and functionalization of degradable hybrid nanogels; (3) the advantages of hybrid nanogels in controlled and targeted delivery; and (4) the analysis of the specificity of drug release mechanisms in hybrid nanogels. The limitations and future directions of hybrid nanogels in targeted specific- and real-time delivery are also discussed. View Full-Text
Keywords: controlled release; targeted delivery; hybrid nanogels; biomolecule–hydrogel nanocomposites; drug delivery systems; smart materials; high-drug loading; on–off systems; remotely controlled release controlled release; targeted delivery; hybrid nanogels; biomolecule–hydrogel nanocomposites; drug delivery systems; smart materials; high-drug loading; on–off systems; remotely controlled release
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Stanislawska, I.; Liwinska, W.; Lyp, M.; Stojek, Z.; Zabost, E. Recent Advances in Degradable Hybrids of Biomolecules and NGs for Targeted Delivery. Molecules 2019, 24, 1873.

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