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Molecules 2019, 24(1), 70; https://doi.org/10.3390/molecules24010070

Influence of Bovine Serum Albumin-Flavonoid Interaction on the Antioxidant Activity of Dietary Flavonoids: New Evidence from Electrochemical Quantification

1,2,†, 3,†, 1,* and 2,*
1
Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha 410205, China
2
Key Laboratory for Green Organic Synthesis and Application of Hunan Province, College of Chemistry, Xiangtan University, Xiangtan 411105, China
3
Zhengzhou Research Base, State Key Laboratory of Cotton Biology, Zhengzhou University, Zhengzhou 450001, China
*
Authors to whom correspondence should be addressed.
These two authors contributed equally to this work.
Received: 15 November 2018 / Revised: 16 December 2018 / Accepted: 18 December 2018 / Published: 25 December 2018
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Abstract

Interaction between dietary flavonoids and albumins plays an important role in the bioavailability and bioactivity of flavonoids. Therefore, the influence of this interaction on the antioxidant activity of flavonoid has attracted much interest. In this study, a ceric reducing/antioxidant capacity assay (CRAC) was employed to investigate the effects of albumin-flavonoid interaction on the antioxidant activity of seven common flavonoids. The results obtained from the CRAC assay were also compared separately with the results from the spectrophotometric methods including 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. All the flavonoids show a decreasing in the antioxidant activity detected by CRAC assay, indicting a “masking effect” of bovine serum albumin (BSA)-flavonoid interaction. However, the results from DPPH and FRAP assays were conflicting, which may be attributed to the influence of solvent systems. View Full-Text
Keywords: antioxidant capacity; BSA-flavonoid interaction; CRAC assay; DPPH assay; FRAP assay antioxidant capacity; BSA-flavonoid interaction; CRAC assay; DPPH assay; FRAP assay
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Geng, R.; Ma, L.; Liu, L.; Xie, Y. Influence of Bovine Serum Albumin-Flavonoid Interaction on the Antioxidant Activity of Dietary Flavonoids: New Evidence from Electrochemical Quantification. Molecules 2019, 24, 70.

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