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Open AccessArticle

Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Haike Road #501, Shanghai 201203, China
Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
Authors to whom correspondence should be addressed.
The authors contribute equally to this work.
Academic Editor: Federica Pellati
Molecules 2018, 23(12), 3274;
Received: 12 November 2018 / Revised: 4 December 2018 / Accepted: 6 December 2018 / Published: 11 December 2018
By investigating of the roots of Salvia miltiorrhiza, which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides (14) that were previously undescribed, along with eight known ones (512). Their structure characteristics were assessed by HR-ESIMS, CD, NMR (1H, 13C, HSQC, HMBC) data analyses. These four newly isolated compounds (14), as well as the other eight compounds (512), show extraordinary protective effects on hydrogen peroxide-induced apoptosis in HS-SY5Y cells. Among them, depside 4 and depside 6 displayed more obviously protective effects than others. View Full-Text
Keywords: Salvia miltiorrhiza; depsides; nerve-protection; HS-SY5Y Salvia miltiorrhiza; depsides; nerve-protection; HS-SY5Y
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MDPI and ACS Style

Jin, Q.; Hu, X.; Deng, Y.; Hou, J.; Lei, M.; Ji, H.; Zhou, J.; Qu, H.; Wu, W.; Guo, D. Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities. Molecules 2018, 23, 3274.

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