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Microfluidic-Based Single-Cell Study: Current Status and Future Perspective

by Haiwa Wu 1, Jing Zhu 2, Yao Huang 3, Daming Wu 3,4 and Jingyao Sun 3,5,*
Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
Department of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, China
State Key Laboratory of Organic-Inorganic Composites, Beijing 100029, China
Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA
Author to whom correspondence should be addressed.
Academic Editors: Lesheng Teng, Zhaogang Yang and Jing Xie
Molecules 2018, 23(9), 2347;
Received: 11 August 2018 / Revised: 5 September 2018 / Accepted: 9 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Application of Novel Method in Pharmaceutical Study)
Investigation of cell behavior under different environments and manual operations can give information in specific cellular processes. Among all cell-based analysis, single-cell study occupies a peculiar position, while it can avoid the interaction effect within cell groups and provide more precise information. Microfluidic devices have played an increasingly important role in the field of single-cell study owing to their advantages: high efficiency, easy operation, and low cost. In this review, the applications of polymer-based microfluidics on cell manipulation, cell treatment, and cell analysis at single-cell level are detailed summarized. Moreover, three mainly types of manufacturing methods, i.e., replication, photodefining, and soft lithography methods for polymer-based microfluidics are also discussed. View Full-Text
Keywords: microfluidics; single-cell study; polymeric; manufacturing microfluidics; single-cell study; polymeric; manufacturing
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Wu, H.; Zhu, J.; Huang, Y.; Wu, D.; Sun, J. Microfluidic-Based Single-Cell Study: Current Status and Future Perspective. Molecules 2018, 23, 2347.

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