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Molecules 2018, 23(9), 2347; https://doi.org/10.3390/molecules23092347

Microfluidic-Based Single-Cell Study: Current Status and Future Perspective

1
Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
2
Department of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
3
College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, China
4
State Key Laboratory of Organic-Inorganic Composites, Beijing 100029, China
5
Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Lesheng Teng, Zhaogang Yang and Jing Xie
Received: 11 August 2018 / Revised: 5 September 2018 / Accepted: 9 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Application of Novel Method in Pharmaceutical Study)
Full-Text   |   PDF [3102 KB, uploaded 13 September 2018]   |  

Abstract

Investigation of cell behavior under different environments and manual operations can give information in specific cellular processes. Among all cell-based analysis, single-cell study occupies a peculiar position, while it can avoid the interaction effect within cell groups and provide more precise information. Microfluidic devices have played an increasingly important role in the field of single-cell study owing to their advantages: high efficiency, easy operation, and low cost. In this review, the applications of polymer-based microfluidics on cell manipulation, cell treatment, and cell analysis at single-cell level are detailed summarized. Moreover, three mainly types of manufacturing methods, i.e., replication, photodefining, and soft lithography methods for polymer-based microfluidics are also discussed. View Full-Text
Keywords: microfluidics; single-cell study; polymeric; manufacturing microfluidics; single-cell study; polymeric; manufacturing
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Wu, H.; Zhu, J.; Huang, Y.; Wu, D.; Sun, J. Microfluidic-Based Single-Cell Study: Current Status and Future Perspective. Molecules 2018, 23, 2347.

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