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Molecules 2018, 23(9), 2344;

Natural Peptides in Drug Discovery Targeting Acetylcholinesterase

Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta 12930, Indonesia
Department of Medical Laboratory Technology, Academy of Health Sciences Guna Bangsa, Condongcatur, Depok, Sleman, Yogyakarta 55283, Indonesia
Faculty of Pharmacy, Sanata Dharma University, Paingan, Maguwoharjo, Depok, Sleman, Yogyakarta 55282, Indonesia
Author to whom correspondence should be addressed.
Received: 28 July 2018 / Revised: 6 September 2018 / Accepted: 12 September 2018 / Published: 13 September 2018
(This article belongs to the Section Bioorganic Chemistry)
PDF [4359 KB, uploaded 13 September 2018]


Acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (AChE) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of Alzheimer’s disease (AD). Natural peptides have received considerable attention as biologically important substances as a source of AChE inhibitors. These natural peptides have high potential pharmaceutical and medicinal values due to their bioactivities as neuroprotective and neurodegenerative treatment activities. These peptides have attracted great interest in the pharmaceutical industries, in order to design potential peptides for use in the prophylactic and therapy purposes. Some natural peptides and their derivatives have high commercial values and have succeeded in reaching the pharmaceutical market. A large number of peptides are already in preclinical and clinical pipelines for treatment of various diseases. This review highlights the recent researches on the various natural peptides and future prospects for AD management. View Full-Text
Keywords: natural peptides; acetylcholinesterase; drug discovery; inhibitor; Alzheimer’s disease natural peptides; acetylcholinesterase; drug discovery; inhibitor; Alzheimer’s disease

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Prasasty, V.; Radifar, M.; Istyastono, E. Natural Peptides in Drug Discovery Targeting Acetylcholinesterase. Molecules 2018, 23, 2344.

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