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Use of Polyamidoamine Dendrimers in Brain Diseases

1
College of Medicine, Central Michigan University, Mt. Pleasant, MI 48859, USA
2
Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA
3
Program in Neuroscience, Central Michigan University, Mt. Pleasant, MI 48859, USA
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Department of Chemistry & Biochemistry, Central Michigan University, Mt. Pleasant, MI 48859, USA
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Department of Psychology, Central Michigan University, Mt. Pleasant, MI 48859, USA
6
Field Neurosciences Institute, St. Mary’s of Michigan, Saginaw, MI 48604, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(9), 2238; https://doi.org/10.3390/molecules23092238
Received: 30 July 2018 / Revised: 24 August 2018 / Accepted: 28 August 2018 / Published: 3 September 2018
(This article belongs to the Section Medicinal Chemistry)
Polyamidoamine (PAMAM) dendrimers are one of the smallest and most precise nanomolecules available today, which have promising applications for the treatment of brain diseases. Each aspect of the dendrimer (core, size or generation, size of cavities, and surface functional groups) can be precisely modulated to yield a variety of nanocarriers for delivery of drugs and genes to brain cells in vitro or in vivo. Two of the most important criteria to consider when using PAMAM dendrimers for neuroscience applications is their safety profile and their potential to be prepared in a reproducible manner. Based on these criteria, features of PAMAM dendrimers are described to help the neuroscience researcher to judiciously choose the right type of dendrimer and the appropriate method for loading the drug to form a safe and effective delivery system to the brain. View Full-Text
Keywords: PAMAM dendrimers; nanoparticles; blood-brain barrier; DNA delivery; drug delivery; neurodegenerative diseases PAMAM dendrimers; nanoparticles; blood-brain barrier; DNA delivery; drug delivery; neurodegenerative diseases
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MDPI and ACS Style

Florendo, M.; Figacz, A.; Srinageshwar, B.; Sharma, A.; Swanson, D.; Dunbar, G.L.; Rossignol, J. Use of Polyamidoamine Dendrimers in Brain Diseases. Molecules 2018, 23, 2238. https://doi.org/10.3390/molecules23092238

AMA Style

Florendo M, Figacz A, Srinageshwar B, Sharma A, Swanson D, Dunbar GL, Rossignol J. Use of Polyamidoamine Dendrimers in Brain Diseases. Molecules. 2018; 23(9):2238. https://doi.org/10.3390/molecules23092238

Chicago/Turabian Style

Florendo, Maria, Alexander Figacz, Bhairavi Srinageshwar, Ajit Sharma, Douglas Swanson, Gary L. Dunbar, and Julien Rossignol. 2018. "Use of Polyamidoamine Dendrimers in Brain Diseases" Molecules 23, no. 9: 2238. https://doi.org/10.3390/molecules23092238

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