Next Article in Journal
Special Issue: Flavoenzymes
Previous Article in Journal
Internalization of Titanium Dioxide Nanoparticles Is Cytotoxic for H9c2 Rat Cardiomyoblasts
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(8), 1956; https://doi.org/10.3390/molecules23081956

Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents

1
Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A.A. 25360 Cali, Colombia
2
Centre for Bioinformatics and Photonics-CIBioFI, Calle 13 No. 100-00, Edificio 320, No. 1069, A.A. 25360 Cali, Colombia
*
Author to whom correspondence should be addressed.
Received: 28 June 2018 / Revised: 23 July 2018 / Accepted: 26 July 2018 / Published: 6 August 2018
(This article belongs to the Section Organic Chemistry)
Full-Text   |   PDF [657 KB, uploaded 6 August 2018]   |  

Abstract

A new series of 1,3,5-triazine-containing 2-pyrazoline derivatives (811)ag was synthesized by cyclocondensation reactions of [(4,6-bis((2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amine]chalcones 7ag with hydrazine hydrate and derivatives. Chalcones 7ag were obtained by Claisen-Schmidt condensation between aromatic aldehydes and triazinic derivative 5, which was synthesized in high yield by a microwave-assisted reaction. Seventeen of the synthesized compounds were selected and tested by the US National Cancer Institute (NCI) for their anticancer activity against 58 different human tumor cell lines. Compounds 7g and 10d,e,g showed important GI50 values ranging from 0.569 to 16.6 µM and LC50 values ranging from 5.15 to >100 µM. View Full-Text
Keywords: 1,3,5-triazines; chalcones; 2-pyrazolones; Claisen–Schmidt reaction; cyclocondensation reactions; microwave irradiation; anticancer activity 1,3,5-triazines; chalcones; 2-pyrazolones; Claisen–Schmidt reaction; cyclocondensation reactions; microwave irradiation; anticancer activity
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Moreno, L.M.; Quiroga, J.; Abonia, R.; Ramírez-Prada, J.; Insuasty, B. Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents. Molecules 2018, 23, 1956.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top