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Molecules 2018, 23(8), 1951; https://doi.org/10.3390/molecules23081951

tert-Butylphenolic Derivatives from Paenibacillus odorifer—A Case of Bioconversion

1
University of Rennes 1, CNRS, ISCR—UMR 6226, F-35000 Rennes, France
2
University of Rennes 1, CNRS, IGDR—UMR 6290, F-35000 Rennes, France
3
Chemistry, Oncogenesis, Stress, Signaling, Centre Eugène Marquis, Université de Rennes 1, INSERM U1242, 35000 Rennes, France
*
Author to whom correspondence should be addressed.
Received: 14 June 2018 / Revised: 21 July 2018 / Accepted: 28 July 2018 / Published: 5 August 2018
(This article belongs to the Special Issue Lichens: Chemistry, Ecological and Biological Activities II)
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Abstract

Two compounds (1) and (2) containing tert-butylphenol groups were, for the first time, produced during the culture of Paenibacillus odorifer, a bacterial strain associated with the crustose lichen, Rhizocarpon geographicum. Their entire structures were identified by one-dimensional (1D) and two-dimensional (2D) NMR and high-resolution electrospray ionisation mass spectrometry (HRESIMS) spectroscopic analyses. Among them, Compound 1 exhibited significant cytotoxicity against B16 murine melanoma and HaCaT human keratinocyte cell lines with micromolar half maximal inhibitory concentration (IC50) values. Furthermore, after supplementation studies, a putative biosynthesis pathway was proposed for Compound 1 throughout a bioconversion by this bacterial strain of butylated hydroxyanisole (BHA), an antioxidant polymer additive. View Full-Text
Keywords: tert-butylphenols; Paenibacillus odorifer; Rhizocarpon geographicum; bioconversion tert-butylphenols; Paenibacillus odorifer; Rhizocarpon geographicum; bioconversion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Nguyen, T.-B.-L.; Delalande, O.; Rouaud, I.; Ferron, S.; Chaillot, L.; Pedeux, R.; Tomasi, S. tert-Butylphenolic Derivatives from Paenibacillus odorifer—A Case of Bioconversion. Molecules 2018, 23, 1951.

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