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Molecules 2018, 23(8), 1933; https://doi.org/10.3390/molecules23081933

Characterization of New Polyphenolic Glycosidic Constituents and Evaluation of Cytotoxicity on a Macrophage Cell Line and Allelopathic Activities of Oryza sativa

1
Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea
2
Department of Pharmacognosy and Phytochemistry, Hamdard University, New Delhi 110062, India
3
Department of Herbal Medicine Resource, Kangwon National University, Samcheok 25949, Korea
4
Process Chemistry and Technology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India
Previously worked in Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea
*
Author to whom correspondence should be addressed.
Received: 13 July 2018 / Revised: 26 July 2018 / Accepted: 28 July 2018 / Published: 2 August 2018
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Abstract

Four new constituents, as 5, 7-dihydroxy-4′-methoxyflavonol-3-O-β-d-arabinopyranosyl-(2′′→1′′′)-O-β-d-arabinopyrnosyl-2′′′-O-3′′′′, 7′′′′-dimethylnonan-1′′′′-oate (1), 5-hydroxy-7, 4′-dimethoxyflavone-5-O-α-d-arabinopyranosyl-(2"→1′′′)-O-α-d-arabinopyranosyl-2′′′-O-3′′′′, 7′′′′-dimethylnonan-1′′′′-oate (2), 5-hydroxy-7, 4′-dimethoxyflavone-5-O-β-d-arabinofuranosyl-(2"→1′′′)-O-β-d-arabinopyranosyl-2′′′-O-lanost-5-ene (3) and 4′,4′′-diferuloxy feruloyl-O-α-d-arabinopyranosyl-(2a→1b)-O-α-d-arabinopyranosyl-(2b→1c)-O-α-d-arabinopyranosyl-(2c→1d)-O-α-d-arabinopyranosyl-(2d→1e)-O-α-d-arabinopyranosyl-2e-3′′′, 7′′′-dimethylnonan-1′′′-oate (4), along with three known compounds (57) were isolated from Oryza sativa leaves and straw. The structures of new and known compounds were elucidated by 1D (1H and 13C NMR) and 2D NMR spectral methods, viz: COSY, HMBC, and HSQC aided by mass techniques and IR spectroscopy. The cytotoxicity of these constituents was assessed by using (RAW 264.7) mouse macrophage cell line, and allelopathic effects of compounds (17) on the germination and seedling growth characteristics such as seedling length and root length of barnyardgrass (Echinochloa oryzicola) were evaluated. Significant inhibitory activity was exhibited by compounds comprising flavone derivatives such as (13) on all of seed germination characteristics. The allelopathic effect of flavone derivatives were more pronounced on seedling length and root length than the germination characteristics. The higher concentration of flavone derivatives showed stronger inhibitory effects, whereas the lower concentrations showed stimulatory effects in some cases. View Full-Text
Keywords: Oryza sativa L.; Gramineae; rice leaves and straw; new chemical constituents; cytotoxicity test; allelopathic activities; E. oryzicola Oryza sativa L.; Gramineae; rice leaves and straw; new chemical constituents; cytotoxicity test; allelopathic activities; E. oryzicola
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Chung, I.-M.; Kwon, C.; An, Y.; Ali, M.; Lee, H.; Lim, J.-D.; Kim, S.; Yang, Y.; Kim, S.-H.; Ahmad, A. Characterization of New Polyphenolic Glycosidic Constituents and Evaluation of Cytotoxicity on a Macrophage Cell Line and Allelopathic Activities of Oryza sativa. Molecules 2018, 23, 1933.

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