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Molecules 2018, 23(8), 1921; https://doi.org/10.3390/molecules23081921

Homogeneous Synthesis of Cationic Chitosan via New Avenue

1,†
,
1,4,†
,
2
,
3,* , 4
and
1,4,*
1
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University (BTBU), Beijing 100048, China
2
Beijing Key Lab of Plant Resource Research and Development, Beijing Technology and Business University, Beijing 100048, China
3
Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University (BTBU), Beijing 100048, China
4
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China
These two authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 27 June 2018 / Revised: 20 July 2018 / Accepted: 24 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue Natural Products Used as Foods and Food Ingredients)
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Abstract

Using a solvent formed of alkali and urea, chitosan was successfully dissolved in a new solvent via the freezing–thawing process. Subsequently, quaternized chitosan (QC) was synthesized using 3-chloro-2-hydroxypropyl trimethyl ammonium chloride (CHPTAC) as the cationic reagent under different incubation times and temperatures in a homogeneous system. QCs cannot be synthesized at temperatures above 60 °C, as gel formation will occur. The structure and properties of the prepared QC were characterized and quaternary groups were comfirmed to be successfully incorporated onto chitosan backbones. The degree of substitution (DS) ranged from 16.5% to 46.8% and the yields ranged from 32.6% to 89.7%, which can be adjusted by changing the molar ratio of the chitosan unit to CHPTAC and the reaction time. QCs inhibits the growth of Alicyclobacillus acidoterrestris effectively. Thus, this work offers a simple and green method of functionalizing chitosan and producing quaternized chitosan with an antibacterial effect for potential applications in the food industry. View Full-Text
Keywords: chitosan; homogeneous system; quaternization; characterization; Alicyclobacillus acidoterrestris chitosan; homogeneous system; quaternization; characterization; Alicyclobacillus acidoterrestris
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Song, H.; Wu, H.; Li, S.; Tian, H.; Li, Y.; Wang, J. Homogeneous Synthesis of Cationic Chitosan via New Avenue. Molecules 2018, 23, 1921.

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