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Molecules 2018, 23(8), 1920; https://doi.org/10.3390/molecules23081920

Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion of Lespedeza cuneata and Their Biological Evaluations

1
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea
2
College of Pharmacy, Kangwon National University, Chuncheon 24341, Korea
3
Sungkyun Biotech Co. Ltd., Suwon 16419, Korea
4
Department of Integrative Plant Science, Chung-Ang University, Anseong 17546, Korea
5
Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea
6
Dankook University Hospital Research Institute of Clinical Medicine, Cheonan 31116, Korea
7
Research & Development Center, Natural Way Co., Ltd., Pocheon 11160, Korea
*
Author to whom correspondence should be addressed.
Received: 9 July 2018 / Revised: 28 July 2018 / Accepted: 30 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue Lignans)
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Abstract

Lespedeza cuneata (Fabaceae), known as Chinese bushclover, has been used in traditional medicines for the treatment of diseases including diabetes, hematuria, and insomnia. As part of a continuing search for bioactive constituents from Korean medicinal plant sources, phytochemical analysis of the aerial portion of L. cuneata led to the isolation of two new lignan glycosides (1,2) along with three known lignan glycosides (37) and nine known flavonoid glycosides (814). Numerous analysis techniques, including 1D and 2D NMR spectroscopy, CD spectroscopy, HR-MS, and chemical reactions, were utilized for structural elucidation of the new compounds (1,2). The isolated compounds were evaluated for their applicability in medicinal use using cell-based assays. Compounds 1 and 46 exhibited weak cytotoxicity against four human breast cancer cell lines (Bt549, MCF7, MDA-MB-231, and HCC70) (IC50 < 30.0 μM). However, none of the isolated compounds showed significant antiviral activity against PR8, HRV1B, or CVB3. In addition, compound 10 produced fewer lipid droplets in Oil Red O staining of mouse mesenchymal stem cells compared to the untreated negative control without altering the amount of alkaline phosphatase staining. View Full-Text
Keywords: Lespedeza cuneata; lignan glycoside; flavonoid glycoside; cytotoxicity; adipocyte and osteoblast differentiation Lespedeza cuneata; lignan glycoside; flavonoid glycoside; cytotoxicity; adipocyte and osteoblast differentiation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Baek, J.; Lee, T.K.; Song, J.-H.; Choi, E.; Ko, H.-J.; Lee, S.; Choi, S.U.; Lee, S.; Yoo, S.-W.; Kim, S.-H.; Kim, K.H. Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion of Lespedeza cuneata and Their Biological Evaluations. Molecules 2018, 23, 1920.

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