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Molecules 2018, 23(7), 1819; https://doi.org/10.3390/molecules23071819

Melatonin in Heart Failure: A Promising Therapeutic Strategy?

Cardioprotection Group, Hatter Institute for Cardiovascular Research in Africa (HICRA), Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa
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Academic Editor: Dun-Xian Tan
Received: 30 June 2018 / Revised: 16 July 2018 / Accepted: 17 July 2018 / Published: 22 July 2018
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Abstract

Heart failure is a multifactorial clinical syndrome characterized by the inability of the heart to pump sufficient blood to the body. Despite recent advances in medical management, poor outcomes in patients with heart failure remain very high. This highlights a need for novel paradigms for effective, preventive and curative strategies. Substantial evidence supports the importance of endogenous melatonin in cardiovascular health and the benefits of melatonin supplementation in various cardiac pathologies and cardiometabolic disorders. Melatonin plays a crucial role in major pathological processes associated with heart failure including ischemic injury, oxidative stress, apoptosis, and cardiac remodeling. In this review, available evidence for the role of melatonin in heart failure is discussed. Current challenges and possible limitations of using melatonin in heart failure are also addressed. While few clinical studies have investigated the role of melatonin in the context of heart failure, current findings from experimental studies support the potential use of melatonin as preventive and adjunctive curative therapy in heart failure. View Full-Text
Keywords: cardiac remodeling; cardioprotection; cardiomyopathy; fibrosis; heart failure; hypertension; ischemic heart disease; melatonin; metabolic syndrome cardiac remodeling; cardioprotection; cardiomyopathy; fibrosis; heart failure; hypertension; ischemic heart disease; melatonin; metabolic syndrome
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Nduhirabandi, F.; Maarman, G.J. Melatonin in Heart Failure: A Promising Therapeutic Strategy? Molecules 2018, 23, 1819.

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