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Molecules 2018, 23(7), 1704; https://doi.org/10.3390/molecules23071704

Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy

1
College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, China
2
Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA
3
State Key Laboratory of Organic-Inorganic Composites, Beijing 100029, China
*
Authors to whom correspondence should be addressed.
Received: 4 June 2018 / Revised: 29 June 2018 / Accepted: 6 July 2018 / Published: 12 July 2018
(This article belongs to the Special Issue Application of Novel Method in Pharmaceutical Study)
Full-Text   |   PDF [1992 KB, uploaded 12 July 2018]   |  

Abstract

Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed. View Full-Text
Keywords: photodynamic therapy; metal-based nanoparticles; potential toxicity photodynamic therapy; metal-based nanoparticles; potential toxicity
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Sun, J.; Kormakov, S.; Liu, Y.; Huang, Y.; Wu, D.; Yang, Z. Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy. Molecules 2018, 23, 1704.

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