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Molecules 2018, 23(7), 1639; https://doi.org/10.3390/molecules23071639

1,10-Secoguaianolides from Artemisia austro-yunnanensis and Their Anti-Inflammatory Effects

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
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Received: 6 June 2018 / Revised: 22 June 2018 / Accepted: 23 June 2018 / Published: 5 July 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Seven 1,10-secoguaianolides 17, including a new one (compound 1), were isolated from Artemisia austro-yunnanensis and identified by HRESIMS and other spectroscopic methods. Their anti-inflammatory effects were evaluated by the model of LPS-induced RAW264.7 cells in vitro. Bioassay results showed that six of them (14, 6 and 7), with the exception of 5, produce some cytotoxicity on RAW264.7 cells at its high dosage, can significantly decrease the release of NO, TNF-α, IL-1β, IL-6 and PGE2 in a dose dependent manner, and down-regulate the expression of proteins iNOS and COX-2. The mechanism study indicated they regulated the NF-κB dependent transcriptional activity through decreasing the phosphorylation of NF-κB. Further, the relationship between their structures and cytokines to anti-inflammatory were studied by PCA and discussed. View Full-Text
Keywords: 1,10-secoguaianolide; anti-inflammation; Artemisia austro-yunnanensis; NF-κB regulation; iNOS inhibition 1,10-secoguaianolide; anti-inflammation; Artemisia austro-yunnanensis; NF-κB regulation; iNOS inhibition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Liu, L.; Dai, W.; Xiang, C.; Chi, J.; Zhang, M. 1,10-Secoguaianolides from Artemisia austro-yunnanensis and Their Anti-Inflammatory Effects. Molecules 2018, 23, 1639.

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