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Keywords = Artemisia austro-yunnanensis

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14 pages, 2959 KB  
Article
1,10-Secoguaianolides from Artemisia austro-yunnanensis and Their Anti-Inflammatory Effects
by Lan Liu, Weifeng Dai, Cheng Xiang, Jun Chi and Mi Zhang
Molecules 2018, 23(7), 1639; https://doi.org/10.3390/molecules23071639 - 5 Jul 2018
Cited by 9 | Viewed by 3914
Abstract
Seven 1,10-secoguaianolides 17, including a new one (compound 1), were isolated from Artemisia austro-yunnanensis and identified by HRESIMS and other spectroscopic methods. Their anti-inflammatory effects were evaluated by the model of LPS-induced RAW264.7 cells in vitro. Bioassay results [...] Read more.
Seven 1,10-secoguaianolides 17, including a new one (compound 1), were isolated from Artemisia austro-yunnanensis and identified by HRESIMS and other spectroscopic methods. Their anti-inflammatory effects were evaluated by the model of LPS-induced RAW264.7 cells in vitro. Bioassay results showed that six of them (14, 6 and 7), with the exception of 5, produce some cytotoxicity on RAW264.7 cells at its high dosage, can significantly decrease the release of NO, TNF-α, IL-1β, IL-6 and PGE2 in a dose dependent manner, and down-regulate the expression of proteins iNOS and COX-2. The mechanism study indicated they regulated the NF-κB dependent transcriptional activity through decreasing the phosphorylation of NF-κB. Further, the relationship between their structures and cytokines to anti-inflammatory were studied by PCA and discussed. Full article
(This article belongs to the Section Natural Products Chemistry)
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