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Structure, Chemical Analysis, Biosynthesis, Metabolism, Molecular Engineering, and Biological Functions of Phytoalexins
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Synergistic Effects of Resveratrol and Pyrimethanil against Botrytis cinerea on Grape

Department of Plant Pathology/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, China
College of Plant Protection, China Agricultural University, Beijing 100193, China
Authors to whom correspondence should be addressed.
Molecules 2018, 23(6), 1455;
Received: 26 April 2018 / Revised: 12 June 2018 / Accepted: 12 June 2018 / Published: 15 June 2018
(This article belongs to the Collection Phytoalexins: Fundamental Aspects and Applications)
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Botrytis cinerea is the pathogen of gray mold disease affecting a wide range of plant hosts, with consequential economic losses worldwide. The increased frequency of fungicide resistance of the pathogen challenges its disease management, and thus the development of alternative control strategies are urgently required. In this study, we showed excellent synergistic interactions between resveratrol and pyrimethanil. Significant synergistic values were recorded by the two-drug combination on the suppression of mycelial growth and conidia germination of B. cinerea. The combination of resveratrol and pyrimethanil caused malformation of mycelia. Moreover, the inoculation assay was conducted on table grape and consistent synergistic suppression of the two-drug combination was found in vivo. Our findings first revealed that the combination of resveratrol and pyrimethanil has synergistic effects against resistant B. cinerea and support the potential use of resveratrol as a promising adjuvant on the control of gray mold. View Full-Text
Keywords: adjuvant; antifungal activity; drug combination; gray mold; resistant isolate adjuvant; antifungal activity; drug combination; gray mold; resistant isolate

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Xu, D.; Yu, G.; Xi, P.; Kong, X.; Wang, Q.; Gao, L.; Jiang, Z. Synergistic Effects of Resveratrol and Pyrimethanil against Botrytis cinerea on Grape. Molecules 2018, 23, 1455.

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