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Design and Efficacy of Nanogels Formulations for Intranasal Administration

Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa
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Author to whom correspondence should be addressed.
Molecules 2018, 23(6), 1241; https://doi.org/10.3390/molecules23061241
Received: 4 April 2018 / Revised: 27 April 2018 / Accepted: 2 May 2018 / Published: 23 May 2018
(This article belongs to the Special Issue Targeted Drug Delivery and Nanocarriers)
Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver drugs to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression. nanogels have also been developed as vaccine carriers for the protection of bacterial infections such as influenza, meningitis, pneumonia and as veterinary vaccine carriers for the protection of animals from encephalomyelitis and mouth to foot disease. It has been developed as vaccine carriers for the prevention of lifestyle disease such as obesity. Intranasal administration of therapeutics using nanogels for the management of brain diseases revealed that the drug transportation was via the olfactory nerve pathway resulting in rapid drug delivery to the brain with excellent neuroprotective effect. The application of nanogels as vaccine carriers also induced significant responses associated with protective immunity against selected bacterial and viral infections. This review provides a detailed information on the enhanced therapeutic effects, mechanisms and biological efficacy of nanogels for intranasal administration. View Full-Text
Keywords: nanogels; depression; hypertension; influenza; HIV; Alzheimer disease; veterinary vaccine; obesity nanogels; depression; hypertension; influenza; HIV; Alzheimer disease; veterinary vaccine; obesity
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Aderibigbe, B.A.; Naki, T. Design and Efficacy of Nanogels Formulations for Intranasal Administration. Molecules 2018, 23, 1241.

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