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Molecules 2018, 23(5), 1065; https://doi.org/10.3390/molecules23051065

Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis

1
ChemBioPharm Team, ARNA Laboratory, INSERM U1212, CNRS UMR 5320, Bordeaux University, F-33000 Bordeaux, France
2
Laboratoire de développement du médicament, Université Ouaga 1 Pr Joseph Ki-Zerbo, Ouaga 03 BP 7021, Burkina Faso
*
Author to whom correspondence should be addressed.
Received: 13 April 2018 / Revised: 25 April 2018 / Accepted: 25 April 2018 / Published: 2 May 2018
(This article belongs to the Special Issue Green Analytical Chemistry)
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Abstract

The greening of analytical methods has gained increasing interest in the field of pharmaceutical analysis to reduce environmental impacts and improve the health safety of analysts. Reversed-phase high-performance liquid chromatography (RP-HPLC) is the most widely used analytical technique involved in pharmaceutical drug development and manufacturing, such as the quality control of bulk drugs and pharmaceutical formulations, as well as the analysis of drugs in biological samples. However, RP-HPLC methods commonly use large amounts of organic solvents and generate high quantities of waste to be disposed, leading to some issues in terms of ecological impact and operator safety. In this context, greening HPLC methods is becoming highly desirable. One strategy to reduce the impact of hazardous solvents is to replace classically used organic solvents (i.e., acetonitrile and methanol) with greener ones. So far, ethanol has been the most often used alternative organic solvent. Others strategies have followed, such as the use of totally aqueous mobile phases, micellar liquid chromatography, and ionic liquids. These approaches have been well developed, as they do not require equipment investments and are rather economical. This review describes and critically discusses the recent advances in greening RP-HPLC methods dedicated to pharmaceutical analysis based on the use of alternative solvents. View Full-Text
Keywords: green liquid chromatography; reversed-phase chromatography; alternative solvents; pharmaceutical analysis; ethanol; micellar liquid chromatography; ionic liquids green liquid chromatography; reversed-phase chromatography; alternative solvents; pharmaceutical analysis; ethanol; micellar liquid chromatography; ionic liquids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Yabré, M.; Ferey, L.; Somé, I.T.; Gaudin, K. Greening Reversed-Phase Liquid Chromatography Methods Using Alternative Solvents for Pharmaceutical Analysis. Molecules 2018, 23, 1065.

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