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Molecularly Imprinted Polymers as Extracting Media for the Chromatographic Determination of Antibiotics in Milk

Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Author to whom correspondence should be addressed.
Molecules 2018, 23(2), 316;
Received: 14 November 2017 / Revised: 26 January 2018 / Accepted: 1 February 2018 / Published: 2 February 2018
(This article belongs to the Special Issue Synthesis and Applications of Molecularly Imprinted Polymers)
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Milk-producing animals are typically kept stationary in overcrowded large-scale farms and in most cases under unsanitary conditions, which promotes the development of infections. In order to maintain sufficient health status among the herd or promote growth and increase production, farmers administer preventative antibiotic doses to the animals through their feed. However, many antibiotics used in cattle farms are intended for the treatment of bacterial infections in humans. This results in the development of antibiotic-resistant bacteria which pose a great risk for public health. Additionally, antibiotic residues are found in milk and dairy products, with potential toxic effects for the consumers. Hence the need of antibiotic residues monitoring in milk arises. Analytical methods were developed for the determination of antibiotics in milk, with key priority given to the analyte extraction and preconcentration step. Extraction can benefit from the production of molecularly imprinted polymers (MIPs) that can be applied as sorbents for the extraction of specific antibiotics. This review focuses on the principals of molecular imprinting technology and synthesis methods of MIPs, as well as the application of MIPs and MIPs composites for the chromatographic determination of various antibiotic categories in milk found in the recent literature. View Full-Text
Keywords: molecularly imprinted polymers; MIPs; antibiotics; milk; extraction; chromatography molecularly imprinted polymers; MIPs; antibiotics; milk; extraction; chromatography

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Bitas, D.; Samanidou, V. Molecularly Imprinted Polymers as Extracting Media for the Chromatographic Determination of Antibiotics in Milk. Molecules 2018, 23, 316.

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