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Open AccessArticle

Anti-Inflammatory, Antioxidant, and Hypolipidemic Effects of Mixed Nuts in Atherogenic Diet-Fed Rats

School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182, USA
Author to whom correspondence should be addressed.
Molecules 2018, 23(12), 3126;
Received: 29 October 2018 / Revised: 26 November 2018 / Accepted: 27 November 2018 / Published: 29 November 2018
(This article belongs to the Collection Bioactive Compounds)
Nut consumption is associated with reduced risk of cardiovascular disease (CVD). Because most studies have administered single nut varieties, it is unknown whether mixed nuts will also reduce CVD risk. The objective of this study was to compare the effects of mixed nut and pistachio consumption on lipid profiles, glucose, inflammation, oxidative stress, and antioxidant capacity in rats fed an atherogenic diet. Thirty male Sprague-Dawley rats (21 days old) were assigned into three groups (n = 10) based on initial body weight and fed either an isocaloric control diet (no nuts), 8.1% pistachio diet (single nut), or 7.5% mixed nut diet (almonds, brazil nuts, cashews, macadamia nuts, peanuts, pecans, pistachios, and walnuts) for 8 weeks. Both pistachios and mixed nuts significantly decreased triglycerides, total cholesterol, and LDL-cholesterol (p < 0.05) compared with controls. Both nut groups exhibited reductions in C-reactive protein (p = 0.045) and oxidative stress (p = 0.004). The mixed nut group had greater superoxide dismutase (p = 0.004) and catalase (p = 0.044) and lower aspartate aminotransferase (p = 0.048) activities. Gene expression for Fas, Hmgcr, and Cox2 was downregulated for both nut groups compared to controls (p < 0.05). In conclusion, mixed nuts and individual nut varieties have comparable effects on CVD risk factors in rats. View Full-Text
Keywords: nuts; pistachio; lipid profile; antioxidant; oxidative stress nuts; pistachio; lipid profile; antioxidant; oxidative stress
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MDPI and ACS Style

Hong, M.Y.; Groven, S.; Marx, A.; Rasmussen, C.; Beidler, J. Anti-Inflammatory, Antioxidant, and Hypolipidemic Effects of Mixed Nuts in Atherogenic Diet-Fed Rats. Molecules 2018, 23, 3126.

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