Next Article in Journal
In Cellulo Protein-mRNA Interaction Assay to Determine the Action of G-Quadruplex-Binding Molecules
Previous Article in Journal
The Degradation Products of Ascorbic Acid Inhibit Amyloid Fibrillation of Insulin and Destabilize Preformed Fibrils
Open AccessArticle

Three Inulin-Type Fructans from Codonopsis pilosula (Franch.) Nannf. Roots and Their Prebiotic Activity on Bifidobacterium longum

by Jiankuan Li 1,2, Xin Zhang 1, Lingya Cao 1,3, Jiaojiao Ji 1,2 and Jianping Gao 1,2,*
1
School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China
2
The Engineering Technology Research Center of Authentic Herbal Material Resources Development of Shanxi Province, Shanxi Medical University, Taiyuan 030001, China
3
School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, China
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(12), 3123; https://doi.org/10.3390/molecules23123123
Received: 6 November 2018 / Revised: 25 November 2018 / Accepted: 27 November 2018 / Published: 29 November 2018
Radix Codonopsis, derived from the roots of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula (Franch.) Nannf. Var. modesta (Nannf.) L.T. Shen and Codonopsis tangshen Oliv., has been used as traditional Chinese medicine for improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis in China. Inulin-type fructans are carbohydrates consisting mainly of β (2→1) fructosyl-fructose links in chemical structure and exhibit a range of properties such as prebiotic activity, fat substitutes in low-calorie foods and disease-modifying effects. The prebiotic effects of inulin-type fructans are hypothesized to improve gastrointestinal function through alterations to gut microbiota composition and metabolism. In the present study, three inulin-type fructans with high degree of polymerization (DP = 16, 22, and 31) were isolated from the roots of Codonopsis pilosula (Franch.) Nannf. and their structures were confirmed by MALDI-TOF-MS, 1D- and 2D-NMR. The prebiotic activity of these fructans was evaluated by detecting growth stimulation on Bifidobacterium longum. The results demonstrated that three fructans at a concentration of 2.0 g/L exhibited significant growth stimulation on Bifidobacterium longum in a time-dependent manner (p < 0.01). The data indicated that inulin-type fructans in Radix Codonopsis could be used as potential prebiotics. View Full-Text
Keywords: Codonopsis pilosula (Franch.) Nannf.; inulin; prebiotic activity; polysaccharide; Bifidobacterium longum Codonopsis pilosula (Franch.) Nannf.; inulin; prebiotic activity; polysaccharide; Bifidobacterium longum
Show Figures

Graphical abstract

MDPI and ACS Style

Li, J.; Zhang, X.; Cao, L.; Ji, J.; Gao, J. Three Inulin-Type Fructans from Codonopsis pilosula (Franch.) Nannf. Roots and Their Prebiotic Activity on Bifidobacterium longum. Molecules 2018, 23, 3123.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop