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Open AccessArticle

Phytochemical Profile, Antioxidant and Antidiabetic Activities of Adansonia digitata L. (Baobab) from Mali, as a Source of Health-Promoting Compounds

1
Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
2
Research Centre for Nutraceutical and Healthy Foods “NUTRAFOOD”, University of Pisa, 56124 Pisa, Italy
3
Department of Science, University of Basilicata, 85100 Potenza, Italy
4
Aide au Développement de la Médecine Traditionnelle (AIDEMET), ONG, Bamako, Mali
5
Département Médecine Traditionelle (DMT), INRSP, B.P. 1746 Bamako, Mali
*
Author to whom correspondence should be addressed.
Academic Editor: Francesco Epifano
Molecules 2018, 23(12), 3104; https://doi.org/10.3390/molecules23123104
Received: 3 November 2018 / Revised: 22 November 2018 / Accepted: 23 November 2018 / Published: 27 November 2018
(This article belongs to the Special Issue Natural Product Isolation, Identification and Biological Activity)
Background: Adansonia digitata L. (Malvaceae), also known as baobab, is a tree attracting recent interest especially due to the high nutritional value of the fruit pulp. However, few studies are reported on the secondary metabolite content, showing high variability depending on the geographic region. Methods: In this study, the chemical profiles of Malian commercial baobab fruits and leaves, focused on phenolic content, were investigated by HPLC coupled with a photodiode array (PDA)/UV and an electrospray ionization (ESI) mass spectrometer (MS) and gas chromatography (GC)/MS. In addition, the extracts of fruit pulps obtained from three different markets (Fruits 1, 2, and 3) were evaluated for their total phenolic content (TPC), antioxidant activity and α-glucosidase inhibition. Results: Baobab fruit pulps were found to be rich in procyanidins and flavonol glycosides, with tiliroside as the major constituent. The baobab leaves showed a similar profile respect to the fruits, but with more detected phenolics. All fruit pulp extracts exerted antioxidant activity (highest for Fruit 3) and higher α-glucosidase inhibition than acarbose used as standard. Conclusions: This study confirmed the variability of baobab with different origins and indicated Malian species baobab as a promising source of health-promoting substances. View Full-Text
Keywords: Adansonia digitata; baobab; phenols; tiliroside; volatile organic compounds; antioxidant activity; antidiabetic activity; LC-ESI-MS/MS Adansonia digitata; baobab; phenols; tiliroside; volatile organic compounds; antioxidant activity; antidiabetic activity; LC-ESI-MS/MS
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Braca, A.; Sinisgalli, C.; De Leo, M.; Muscatello, B.; Cioni, P.L.; Milella, L.; Ostuni, A.; Giani, S.; Sanogo, R. Phytochemical Profile, Antioxidant and Antidiabetic Activities of Adansonia digitata L. (Baobab) from Mali, as a Source of Health-Promoting Compounds. Molecules 2018, 23, 3104.

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