Next Article in Journal
Native Quercetin as a Chloride Receptor in an Organic Solvent
Next Article in Special Issue
Cycloartane and Oleanane Glycosides from the Tubers of Eranthis cilicica
Previous Article in Journal
Agar Extraction By-Products from Gelidium sesquipedale as a Source of Glycerol-Galactosides
Previous Article in Special Issue
Phytochemical Profile, Antioxidant and Antidiabetic Activities of Adansonia digitata L. (Baobab) from Mali, as a Source of Health-Promoting Compounds
Open AccessArticle

Identification of Pinocembrin as an Anti-Glycation Agent and α-Glucosidase Inhibitor from Fingerroot (Boesenbergia rotunda): The Tentative Structure–Activity Relationship towards MG-Trapping Activity

1
Program of Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
2
Center of Excellence in Natural Products, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
3
Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand
4
Department of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, Indonesia
*
Author to whom correspondence should be addressed.
Academic Editor: Francesco Epifano
Molecules 2018, 23(12), 3365; https://doi.org/10.3390/molecules23123365
Received: 15 November 2018 / Revised: 12 December 2018 / Accepted: 15 December 2018 / Published: 19 December 2018
(This article belongs to the Special Issue Natural Product Isolation, Identification and Biological Activity)
Diabetes mellitus (DM) is a disease that is caused by a malfunction of carbohydrate metabolism, which plays an important role in the development of long-term diabetic complications. The excess glucose can be transformed to methylglyoxal (MG), a potential precursor of glycation. Glycation is a spontaneous non-enzymatic reaction that initially yields advanced glycation end-products (AGEs), which ultimately triggers several severe complications. Therefore, the inhibition of AGEs formation is the imperative approach for alleviating diabetic complications. The aim of this research was to investigate the glycation and α-glucosidase inhibitory abilities of compounds isolated from fingerroot. The dichloromethane extract afforded three flavanones, two chalcones, two dihydrochalcones, and one kavalactone. Most of the isolated compounds showed higher inhibition effect against AGEs formation than aminoguanidine (AG). Subsequent evaluation in MG-trapping assay indicated that their trapping potency was relatively comparable to AG. Their structure-activity relationships (SAR) of MG-trapping activity were investigated using the comparison of the structures of flavonoids. In addition, pinocembrin displayed moderate α-glucosidase inhibition against both maltase and sucrose, with IC50 values of 0.35 ± 0.021 and 0.39 ± 0.020 mM, respectively. View Full-Text
Keywords: α-glucosidase; Boesenbergia rotunda; advanced glycation end-products; methylglyoxal; pinocembrin; structure-activity relationship; diabetes α-glucosidase; Boesenbergia rotunda; advanced glycation end-products; methylglyoxal; pinocembrin; structure-activity relationship; diabetes
Show Figures

Graphical abstract

MDPI and ACS Style

Potipiranun, T.; Adisakwattana, S.; Worawalai, W.; Ramadhan, R.; Phuwapraisirisan, P. Identification of Pinocembrin as an Anti-Glycation Agent and α-Glucosidase Inhibitor from Fingerroot (Boesenbergia rotunda): The Tentative Structure–Activity Relationship towards MG-Trapping Activity. Molecules 2018, 23, 3365.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop