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Open AccessArticle

Angelica Stem: A Potential Low-Cost Source of Bioactive Phthalides and Phytosterols

by Chengke Zhao 1, Yuan Jia 1 and Fachuang Lu 1,2,*
1
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China
2
Guangdong Engineering Research Center for Green Fine Chemicals, Guangzhou 510640, China
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(12), 3065; https://doi.org/10.3390/molecules23123065
Received: 1 November 2018 / Revised: 19 November 2018 / Accepted: 20 November 2018 / Published: 23 November 2018
(This article belongs to the Section Natural Products Chemistry)
Chinese Angelica is a significant medical plant due to the various therapeutic constituents in its root; whereas the aerial part is considered worthless and often discarded as agricultural waste. In this work, phytochemicals from the stem were first systematically analyzed by means of GC–MS after derivatization and HPLC–MS/MS in multiple reaction monitoring (MRM) mode. Phthalides, ferulic acid, and coniferyl ferulate were detected in the stem; although their content is relatively low in comparison with the root. Some specific compounds, such as p-hydroxybenzoic acid, vanillic acid, protocatechuic acid, caffeic acid, 4-hydroxyphenyl-1, 2-ethanediol, thymol-β-d-glucopyranoside, etc. and a significant amount of phytosterols (1.36 mg/g stem, mainly β-sitosterol) were detected in the stem. The extracted oil from the stem contained a considerable amount of phthalides (48.5 mg/g), β-sitosterol (56.21 mg/g), and stigmasterol (14.03 mg/g); no other bioactive compounds were found that could be potentially used as pharmaceuticals or additives to healthcare food. View Full-Text
Keywords: Angelica sinensis; bioactive compounds; GC–MS; phthalides; coniferyl ferulate; phytosterols Angelica sinensis; bioactive compounds; GC–MS; phthalides; coniferyl ferulate; phytosterols
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MDPI and ACS Style

Zhao, C.; Jia, Y.; Lu, F. Angelica Stem: A Potential Low-Cost Source of Bioactive Phthalides and Phytosterols. Molecules 2018, 23, 3065.

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