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Open AccessArticle

Antibacterial Activities of Metabolites from Vitis rotundifolia (Muscadine) Roots against Fish Pathogenic Bacteria

1
United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, National Center for Natural Products Research, Post Office Box 1848, University, MS 38677, USA
2
Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki, Giza 12622, Egypt
3
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
4
Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(11), 2761; https://doi.org/10.3390/molecules23112761
Received: 18 September 2018 / Revised: 21 October 2018 / Accepted: 22 October 2018 / Published: 25 October 2018
Enteric septicemia of catfish, columnaris disease and streptococcosis, caused by Edwardsiella ictaluri, Flavobacterium columnare and Streptococcus iniae, respectively, are the most common bacterial diseases of economic significance to the pond-raised channel catfish Ictalurus punctatus industry. Certain management practices are used by catfish farmers to prevent large financial losses from these diseases such as the use of commercial antibiotics. In order to discover environmentally benign alternatives, using a rapid bioassay, we evaluated a crude extract from the roots of muscadine Vitis rotundifolia against these fish pathogenic bacteria and determined that the extract was most active against F. columnare. Subsequently, several isolated compounds from the root extract were isolated. Among these isolated compounds, (+)-hopeaphenol (2) and (+)-vitisin A (3) were found to be the most active (bacteriostatic activity only) against F. columnare, with 24-h 50% inhibition concentrations of 4.0 ± 0.7 and 7.7 ± 0.6 mg/L, respectively, and minimum inhibitory concentrations of 9.1 ± 0 mg/L for each compound which were approximately 25X less active than the drug control florfenicol. Efficacy testing of 2 and 3 is necessary to further evaluate the potential for these compounds to be used as antibacterial agents for managing columnaris disease. View Full-Text
Keywords: antibacterial; channel catfish; columnaris disease; Flavobacterium columnare; stilbenes; muscadine; pyranoanthocyanin antibacterial; channel catfish; columnaris disease; Flavobacterium columnare; stilbenes; muscadine; pyranoanthocyanin
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MDPI and ACS Style

Schrader, K.K.; Ibrahim, M.A.; Abd-Alla, H.I.; Cantrell, C.L.; Pasco, D.S. Antibacterial Activities of Metabolites from Vitis rotundifolia (Muscadine) Roots against Fish Pathogenic Bacteria. Molecules 2018, 23, 2761.

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