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Molecules 2018, 23(10), 2638; https://doi.org/10.3390/molecules23102638

Anti-Proliferative Effects of HBX-5 on Progression of Benign Prostatic Hyperplasia

1
Department of Pharmacology, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju-si, Gangwon-do 26339, Korea
2
Department of Meridian & Acupoint, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju-si, Gangwon-do 26339, Korea
3
Central Research Institue of Hawon Pharmaceutical, Jangheung 59338, Korea
*
Author to whom correspondence should be addressed.
Received: 5 September 2018 / Revised: 8 October 2018 / Accepted: 13 October 2018 / Published: 14 October 2018
(This article belongs to the Collection Herbal Medicine Research)
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Abstract

Benign prostatic hyperplasia (BPH), an age-dependent disorder with a prevalence percentage of 60% in the 60s, has been found to involve an androgenic hormone imbalance that causes confusion between cell apoptosis and proliferation. Because general medications for BPH treatment have undesirable side effects, the development of effective alternative medicines has been considered. HBX-5 is a newly developed formula with the aim of improving BPH, and is composed of nine medicinal herbs. BPH was induced in the rats by intramuscular injection of testosterone propionate after castration. Rats were divided into six groups, and the efficacy of HBX-5 on testosterone-induced BPH in rats was estimated. In addition, RWPE-1 and WPMY-1 cells were used to demonstrate the effect of HBX-5 on BPH in vitro model. Compared with the control group, HBX-5 administration group suppressed BPH manifestations, such as excessive development of prostate, and increase of serum dihydrotestosterone and 5α-reductase concentrations. Furthermore, immunohistochemistry analysis revealed that HBX-5 significantly decreased the expression of androgen receptor (AR) and proliferating cell nuclear antigen (PCNA). In addition, results of RWPE-1 and WPMY-1 cells showed that HBX-5 inhibited the over-expression of AR and PSA in DHT-induced prostate hyperplastic microenvironments. View Full-Text
Keywords: BPH; HBX-5; proliferation; inflammation; RWPE-1; WPMY-1; testosterone-induced BPH rat model BPH; HBX-5; proliferation; inflammation; RWPE-1; WPMY-1; testosterone-induced BPH rat model
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Jin, B.-R.; Kim, H.-J.; Park, S.-K.; Kim, M.-S.; Lee, K.-H.; Yoon, I.-J.; An, H.-J. Anti-Proliferative Effects of HBX-5 on Progression of Benign Prostatic Hyperplasia. Molecules 2018, 23, 2638.

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