Next Article in Journal
The Major Chromophore Arising from Glucose Degradation and Oxidative Stress Occurrence during Lens Proteins Glycation Induced by Glucose
Next Article in Special Issue
Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation
Previous Article in Journal
The Effect of Resveratrol on Cell Viability in the Burkitt’s Lymphoma Cell Line Ramos
Previous Article in Special Issue
Bioactive Compounds from the Stems of Clausena lansium
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(1), 13;

Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)

Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon
Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany
Department of Chemistry, University of Buea, Faculty of Sciences, 63 Buea, Cameroon
Authors to whom correspondence should be addressed.
Received: 25 November 2017 / Revised: 19 December 2017 / Accepted: 21 December 2017 / Published: 21 December 2017
(This article belongs to the Collection Bioactive Compounds)
Full-Text   |   PDF [420 KB, uploaded 21 December 2017]   |  


Three new prenylated furoquinoline alkaloids named lecomtequinoline A (1), B (2), and C (3), together with the known compounds anhydroevoxine (4), evoxine (5), dictamnine (6), N-methylflindersine (7), evoxanthine (8), hesperidin, lupeol, β-sitosterol, stigmasterol, β-sitosterol-3-O-β-d-glucopyranoside, stearic acid, and myristyl alcohol, were isolated by bioassay-guided fractionation of the methanolic extracts of leaves and stem of Vepris lecomteana. The structures of compounds were determined by spectroscopic methods (NMR, MS, UV, and IR) and by comparison with previously reported data. Crude extracts of leaves and stem displayed high antimicrobial activity, with Minimum Inhibitory Concentration (MIC) (values of 10.1–16.5 and 10.2–20.5 µg/mL, respectively, against Escherichia coli, Bacillus subtilis, Pseudomonas agarici, Micrococcus luteus, and Staphylococcus warneri, while compounds 16 showed values ranging from 11.1 to 18.7 µg/mL or were inactive, suggesting synergistic effect. The extracts may find application in crude drug preparations in Western Africa where Vepris lecomteana is endemic, subject to negative toxicity results in vivo. View Full-Text
Keywords: Vepris lecomteana; furoquinoline alkaloids; lecomte quinoline A–C Vepris lecomteana; furoquinoline alkaloids; lecomte quinoline A–C

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Kouam, A.D.K.; Bissoue, A.N.; Tcho, A.T.; Happi, E.N.; Waffo, A.F.K.; Sewald, N.; Wansi, J.D. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae). Molecules 2018, 23, 13.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top