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Molecules 2018, 23(1), 51;

Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation

Liaoning Provincial Key Laboratory of Carbohydrates, Dalian Institute of Chemical Physics Chinese Academy of Sciences, Dalian 116023, China
University of Chinese Academy of Sciences, Beijing 100049, China
State Key Laboratory of Biochemical Engineering and Key Laboratory of Biopharmaceutical Production & Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, China
Authors to whom correspondence should be addressed.
Received: 17 November 2017 / Revised: 19 December 2017 / Accepted: 22 December 2017 / Published: 26 December 2017
(This article belongs to the Collection Bioactive Compounds)
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Antrodia cinnamomea (AC), an edible fungus growing in Taiwan, has various health benefits. This study was designed to examine the potential inhibitory effects of AC oligosaccharides on lipopolysaccharide (LPS)-induced inflammatory responses in vitro and in vivo. By trifluoroacetic acid degradation, two oligosaccharide products were prepared from AC polysaccharides at 90 °C (ACHO) or 25 °C (ACCO), which showed different oligosaccharide identities. Compared to ACCO, ACHO displayed better inhibitory effects on LPS-induced mRNA expression of pro-inflammatory cytokines including IL-6, IL-8, IL-1β, TNF-α and MCP-1 in macrophage cells. Further, ACHO significantly suppressed the inflammation in lung tissues of LPS-injected C57BL/6 mice. The potential anti-inflammatory molecular mechanism may be associated with the promotion of protein O-GlcNAcylation, which further skewed toward the marked suppression of p38 and Akt phosphorylation. Our results suggest that the suppressive effect of AC oligosaccharides on inflammation may be an effective approach for the prevention of inflammation-related diseases. View Full-Text
Keywords: Antrodia cinnamomea; Akt; inflammation; O-GlcNAcylation; oligosaccharides Antrodia cinnamomea; Akt; inflammation; O-GlcNAcylation; oligosaccharides

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Zheng, J.; Jiao, S.; Li, Q.; Jia, P.; Yin, H.; Zhao, X.; Du, Y.; Liu, H. Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation. Molecules 2018, 23, 51.

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