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Essential Oils and Their Constituents: An Alternative Source for Novel Antidepressants

Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa, PB 58051-970, Brazil
Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, Natal, RN 59078-970, Brazil
Author to whom correspondence should be addressed.
Molecules 2017, 22(8), 1290;
Received: 6 July 2017 / Revised: 31 July 2017 / Accepted: 31 July 2017 / Published: 3 August 2017
(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
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Depression is a disease that has affected a high proportion of the world’s population and people of different ages, incapacitating them from good performance at work and in social relationships, and causing emotional disorders to millions of families. Therefore, the search for new therapeutic agents is considered a priority for the discovery of more effective forms of treatment. In this review, studies of essential oils and their constituents in experimental models related to depression are discussed. The mechanisms of action of the oils and the presence of psychoactive constituents in their chemical compositions are discussed. The data in the review show the therapeutic potential of essential oils and their chemical constituents for use in depressive disorders. Advanced studies using humans are needed to confirm the antidepressant properties described in animals. View Full-Text
Keywords: oil; terpene; natural products; major depression; antidepressant; animal models oil; terpene; natural products; major depression; antidepressant; animal models
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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De Sousa, D.P.; Silva, R.H.N.; Silva, E.F.; Gavioli, E.C. Essential Oils and Their Constituents: An Alternative Source for Novel Antidepressants. Molecules 2017, 22, 1290.

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