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Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine

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Department of Microbiology, Faculty of Biology, University of Bucharest, 1–3 Aleea Portocalelor Str., 60101 Bucharest, Romania
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Environment and Earth Sciences Department, Research Institute of the University of Bucharest—ICUB, Life, Spl. Independentei 91–95, 010271 Bucharest, Romania
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Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90–92 Panduri Str., 050663 Bucharest, Romania
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Stefan S Nicolau Institute of Virology, 285 Mihai Bravu Ave., 030304 Bucharest, Romania
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Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany
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Authors to whom correspondence should be addressed.
Molecules 2017, 22(7), 1233; https://doi.org/10.3390/molecules22071233
Received: 22 June 2017 / Revised: 19 July 2017 / Accepted: 19 July 2017 / Published: 22 July 2017
(This article belongs to the Section Organometallic Chemistry)
Three complexes, namely [Co(dmtp)2(OH2)4][CoCl4] (1), [Co(dmtp)2Cl2] (2) and [Co(dmtp)2(OH2)4]Cl2∙2H2O (3) (dmtp: 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine), were synthesized and characterized by spectral (IR, UV-Vis-NIR), and magnetic measurements at room temperature, as well as single crystal X-ray diffraction. Complex (1) crystallizes in monoclinic system (space group C2/c), complex (2) adopts an orthorhombic system (space group Pbca), and complex (3) crystallizes in triclinic system (space group P1). Various types of extended hydrogen bonds and π–π interactions provide a supramolecular architecture for all complexes. All species were evaluated for antimicrobial activity towards planktonic and biofilm-embedded microbial cells and influence on HEp-2 cell viability, cellular cycle and gene expression. View Full-Text
Keywords: Co(II) complex; 1,2,4-triazolo[1,5-a]pyrimidine; cis-disposition; biofilm; cytotoxicity Co(II) complex; 1,2,4-triazolo[1,5-a]pyrimidine; cis-disposition; biofilm; cytotoxicity
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MDPI and ACS Style

Măruţescu, L.; Calu, L.; Chifiriuc, M.C.; Bleotu, C.; Daniliuc, C.-G.; Fălcescu, D.; Kamerzan, C.M.; Badea, M.; Olar, R. Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine. Molecules 2017, 22, 1233. https://doi.org/10.3390/molecules22071233

AMA Style

Măruţescu L, Calu L, Chifiriuc MC, Bleotu C, Daniliuc C-G, Fălcescu D, Kamerzan CM, Badea M, Olar R. Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine. Molecules. 2017; 22(7):1233. https://doi.org/10.3390/molecules22071233

Chicago/Turabian Style

Măruţescu, Luminiţa, Larisa Calu, Mariana Carmen Chifiriuc, Coralia Bleotu, Constantin-Gabriel Daniliuc, Denisa Fălcescu, Crina Maria Kamerzan, Mihaela Badea, and Rodica Olar. 2017. "Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine" Molecules 22, no. 7: 1233. https://doi.org/10.3390/molecules22071233

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