Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin
AbstractAn efficient synthesis of a series of 4′-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by 1H-NMR, 13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4′-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents. View Full-Text
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Escobar, B.; Montenegro, I.; Villena, J.; Werner, E.; Godoy, P.; Olguín, Y.; Madrid, A. Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin. Molecules 2017, 22, 968.
Escobar B, Montenegro I, Villena J, Werner E, Godoy P, Olguín Y, Madrid A. Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin. Molecules. 2017; 22(6):968.Chicago/Turabian Style
Escobar, Beatriz; Montenegro, Iván; Villena, Joan; Werner, Enrique; Godoy, Patricio; Olguín, Yusser; Madrid, Alejandro. 2017. "Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin." Molecules 22, no. 6: 968.
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