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Chemical Methods to Knock Down the Amyloid Proteins

Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
Beijing Institute for Brain Disorders, Beijing 100069, China
Author to whom correspondence should be addressed.
Academic Editors: Margaret A. Brimble CNZM, FRSNZ and Derek McPhee
Molecules 2017, 22(6), 916;
Received: 5 March 2017 / Revised: 20 May 2017 / Accepted: 20 May 2017 / Published: 1 June 2017
(This article belongs to the Special Issue Women in Organic Chemistry)
Amyloid proteins are closely related with amyloid diseases and do tremendous harm to human health. However, there is still a lack of effective strategies to treat these amyloid diseases, so it is important to develop novel methods. Accelerating the clearance of amyloid proteins is a favorable method for amyloid disease treatment. Recently, chemical methods for protein reduction have been developed and have attracted much attention. In this review, we focus on the latest progress of chemical methods that knock down amyloid proteins, including the proteolysis-targeting chimera (PROTAC) strategy, the “recognition-cleavage” strategy, the chaperone-mediated autophagy (CMA) strategy, the selectively light-activatable organic and inorganic molecules strategy and other chemical strategies. View Full-Text
Keywords: amyloid proteins; chemical methods; degradation amyloid proteins; chemical methods; degradation
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MDPI and ACS Style

Gao, N.; Chen, Y.-X.; Zhao, Y.-F.; Li, Y.-M. Chemical Methods to Knock Down the Amyloid Proteins. Molecules 2017, 22, 916.

AMA Style

Gao N, Chen Y-X, Zhao Y-F, Li Y-M. Chemical Methods to Knock Down the Amyloid Proteins. Molecules. 2017; 22(6):916.

Chicago/Turabian Style

Gao, Na, Yong-Xiang Chen, Yu-Fen Zhao, and Yan-Mei Li. 2017. "Chemical Methods to Knock Down the Amyloid Proteins" Molecules 22, no. 6: 916.

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