Next Article in Journal
Exploring Adenosine Receptor Ligands: Potential Role in the Treatment of Cardiovascular Diseases
Next Article in Special Issue
β-Formyl- and β-Vinylporphyrins: Magic Building Blocks for Novel Porphyrin Derivatives
Previous Article in Journal
Alternative Access to Functionalized 2,8-Ethanonoradamantane Derivatives
Previous Article in Special Issue
Exploring Anti-Prion Glyco-Based and Aromatic Scaffolds: A Chemical Strategy for the Quality of Life
Open AccessReview

Chemical Methods to Knock Down the Amyloid Proteins

1
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
2
Beijing Institute for Brain Disorders, Beijing 100069, China
*
Author to whom correspondence should be addressed.
Academic Editors: Margaret A. Brimble CNZM, FRSNZ and Derek McPhee
Molecules 2017, 22(6), 916; https://doi.org/10.3390/molecules22060916
Received: 5 March 2017 / Revised: 20 May 2017 / Accepted: 20 May 2017 / Published: 1 June 2017
(This article belongs to the Special Issue Women in Organic Chemistry)
Amyloid proteins are closely related with amyloid diseases and do tremendous harm to human health. However, there is still a lack of effective strategies to treat these amyloid diseases, so it is important to develop novel methods. Accelerating the clearance of amyloid proteins is a favorable method for amyloid disease treatment. Recently, chemical methods for protein reduction have been developed and have attracted much attention. In this review, we focus on the latest progress of chemical methods that knock down amyloid proteins, including the proteolysis-targeting chimera (PROTAC) strategy, the “recognition-cleavage” strategy, the chaperone-mediated autophagy (CMA) strategy, the selectively light-activatable organic and inorganic molecules strategy and other chemical strategies. View Full-Text
Keywords: amyloid proteins; chemical methods; degradation amyloid proteins; chemical methods; degradation
Show Figures

Figure 1

MDPI and ACS Style

Gao, N.; Chen, Y.-X.; Zhao, Y.-F.; Li, Y.-M. Chemical Methods to Knock Down the Amyloid Proteins. Molecules 2017, 22, 916.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop