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Molecules
Volume 22
Issue 4
10.3390/molecules22040641
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Article

Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging

by
Qinghua Xie
1,2,†,
Hua Zhu
2,†,
Feng Wang
2,
Xiangxi Meng
3,
Qiushi Ren
3,
Chuanqin Xia
1,* and
Zhi Yang
2,*
1
College of Chemistry, Sichuan University, Chengdu 610064, China
2
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
3
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editor: Derek J. McPhee
Molecules 2017, 22(4), 641; https://doi.org/10.3390/molecules22040641
Received: 21 February 2017 / Revised: 4 April 2017 / Accepted: 11 April 2017 / Published: 17 April 2017
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Abstract

Copper-64 is a useful radioisotope for positron emission tomography (PET). Due to the wide range of applications, the demand of 64Cu with low metallic impurities is increasing. Here we report a simple method for the efficient production of high specific activity 64Cu using a cyclotron for biomedical application. We designed new equipment based on the plating of enriched 64Ni as the target, and used automated ion exchange chromatography to purify copper-64 efficiently after irradiation and dissolution of the target in good radiochemical and chemical yield and purity. The 64Cu radionuclide produced using 99.32% enriched 64Ni with a density of 61.4 ± 5.0 mg/cm2, reaching a total radioactivity greater than 200 mCi, with specific activity up to 5.6 GBq/μmoL. It was further incorporated into modified monoclonal antibody DOTA-rituximab to synthesize 64Cu-DOTA-rituximab, which was used successfully for micro-PET imaging. View Full-Text
Keywords: copper-64; solid target; Rituximab; positron emission tomography (PET) copper-64; solid target; Rituximab; positron emission tomography (PET)
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MDPI and ACS Style

Xie, Q.; Zhu, H.; Wang, F.; Meng, X.; Ren, Q.; Xia, C.; Yang, Z. Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging. Molecules 2017, 22, 641. https://doi.org/10.3390/molecules22040641

AMA Style

Xie Q, Zhu H, Wang F, Meng X, Ren Q, Xia C, Yang Z. Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging. Molecules. 2017; 22(4):641. https://doi.org/10.3390/molecules22040641

Chicago/Turabian Style

Xie, Qinghua, Hua Zhu, Feng Wang, Xiangxi Meng, Qiushi Ren, Chuanqin Xia, and Zhi Yang. 2017. "Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging" Molecules 22, no. 4: 641. https://doi.org/10.3390/molecules22040641

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